Action of alpha-tocopherol on vanadium-stimulated lipid peroxidation in rat brain.

Sodium metavanadate (2.5, 3.5 or 5.0 mg/kg) administration to rats, intraperitoneally, for 7, 3 or 2 consecutive days was found to enhance lipid peroxidation in various rat brain fractions. However, administration of alpha-tocopherol (335 or 585 mg/kg) in combination with sodium metavanadate decreased the vanadium-stimulated lipid peroxidation. Results revealed that vanadium directly triggered peroxidative reaction and alpha-tocopherol protected against vanadium-stimulated lipid peroxidation.