Literature DB >> 20139621

Expression of mutant RPA in human cancer cells causes telomere shortening.

Yuka Kobayashi1, Koichiro Sato, Tatsuya Kibe, Hiroyuki Seimiya, Asako Nakamura, Masashi Yukawa, Eiko Tsuchiya, Masaru Ueno.   

Abstract

Replication protein A (RPA) binds to single-stranded DNA generated during DNA replication and other processes. The roles of RPA in telomere maintenance have been demonstrated in yeasts, but not in telomerase-positive human cells. In this study, we found that expression of mutant RPA70 in human cells caused telomere shortening, suggesting that RPA is required for telomere-length regulation in human cancer cells.

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Year:  2010        PMID： 20139621     DOI： 10.1271/bbb.90496

Source DB:  PubMed          Journal:  Biosci Biotechnol Biochem        ISSN： 0916-8451            Impact factor:   2.043


  8 in total

1.  A protein array screen for Kaposi's sarcoma-associated herpesvirus LANA interactors links LANA to TIP60, PP2A activity, and telomere shortening.

Authors:  Meir Shamay; Jianyong Liu; Renfeng Li; Gangling Liao; Li Shen; Melanie Greenway; Shaohui Hu; Jian Zhu; Zhi Xie; Richard F Ambinder; Jiang Qian; Heng Zhu; S Diane Hayward
Journal:  J Virol       Date:  2012-02-29       Impact factor: 5.103

2.  5' to 3' Unfolding Directionality of DNA Secondary Structures by Replication Protein A: G-QUADRUPLEXES AND DUPLEXES.

Authors:  Layal Safa; Nassima Meriem Gueddouda; Frédéric Thiébaut; Emmanuelle Delagoutte; Irina Petruseva; Olga Lavrik; Oscar Mendoza; Anne Bourdoncle; Patrizia Alberti; Jean-François Riou; Carole Saintomé
Journal:  J Biol Chem       Date:  2016-07-19       Impact factor: 5.157

3.  Functional Diversification of Replication Protein A Paralogs and Telomere Length Maintenance in Arabidopsis.

Authors:  Behailu B Aklilu; François Peurois; Carole Saintomé; Kevin M Culligan; Daniela Kobbe; Catherine Leasure; Michael Chung; Morgan Cattoor; Ryan Lynch; Lauren Sampson; John Fatora; Dorothy E Shippen
Journal:  Genetics       Date:  2020-06-12       Impact factor: 4.562

4.  Identification of the DNA-Binding Domains of Human Replication Protein A That Recognize G-Quadruplex DNA.

Authors:  Aishwarya Prakash; Amarnath Natarajan; Luis A Marky; Michel M Ouellette; Gloria E O Borgstahl
Journal:  J Nucleic Acids       Date:  2011-05-21

5.  Stabilization of a G-Quadruplex from Unfolding by Replication Protein A Using Potassium and the Porphyrin TMPyP4.

Authors:  Aishwarya Prakash; Fabien Kieken; Luis A Marky; Gloria E O Borgstahl
Journal:  J Nucleic Acids       Date:  2011-06-16

6.  Investigating the Effect of Mono- and Dimeric 360A G-Quadruplex Ligands on Telomere Stability by Single Telomere Length Analysis (STELA).

Authors:  In Pyo Hwang; Patrick Mailliet; Virginie Hossard; Jean-Francois Riou; Anthony Bugaut; Lauréline Roger
Journal:  Molecules       Date:  2019-02-06       Impact factor: 4.411

7.  Gain-of-function mutations in RPA1 cause a syndrome with short telomeres and somatic genetic rescue.

Authors:  Richa Sharma; Sushree S Sahoo; Masayoshi Honda; Sophie L Granger; Charnise Goodings; Louis Sanchez; Axel Künstner; Hauke Busch; Fabian Beier; Shondra M Pruett-Miller; Marcus B Valentine; Alfonso G Fernandez; Ti-Cheng Chang; Vincent Géli; Dmitri Churikov; Sandrine Hirschi; Victor B Pastor; Melanie Boerries; Melchior Lauten; Charikleia Kelaidi; Megan A Cooper; Sarah Nicholas; Jill A Rosenfeld; Sophia Polychronopoulou; Caroline Kannengiesser; Carole Saintomé; Charlotte M Niemeyer; Patrick Revy; Marc S Wold; Maria Spies; Miriam Erlacher; Stéphane Coulon; Marcin W Wlodarski
Journal:  Blood       Date:  2022-02-17       Impact factor: 22.113

8.  iPSC modeling of severe aplastic anemia reveals impaired differentiation and telomere shortening in blood progenitors.

Authors:  Dario Melguizo-Sanchis; Yaobo Xu; Dheraj Taheem; Min Yu; Katarzyna Tilgner; Tomas Barta; Katja Gassner; George Anyfantis; Tengfei Wan; Ramu Elango; Sameer Alharthi; Ashraf A El-Harouni; Stefan Przyborski; Soheir Adam; Gabriele Saretzki; Sujith Samarasinghe; Lyle Armstrong; Majlinda Lako
Journal:  Cell Death Dis       Date:  2018-01-26       Impact factor: 8.469
  8 in total

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