| Literature DB >> 20138800 |
Shu-Chun Lin1, Chung-Ji Liu, Jung-An Lin, Wei-Fan Chiang, Pei-Shih Hung, Kuo-Wei Chang.
Abstract
MicroRNAs (miRNAs) play important roles in neoplastic process. miR-24 is localized on chromosome 9q22 and 19p13, regions frequently altered in oral squamous cell carcinoma (OSCC). This study showed that miR-24 was up-regulated in OSCC tissues relative to control samples. In addition, the plasma levels of miR-24 in OSCC patients were significantly higher than in control individuals. miR-24 expression was also higher in OSCC cell lines relative to normal oral keratinocytes. Experiments blocking miR-24 and using exogenous miR-24 expression indicated that miR-24 contributes to the growth of OSCC cells and that miR-24 may target p57. This study suggests that miR-24 is involved in the regulation of OSCC growth and that the miR-24's level in plasma may be validatable as a tumor marker for OSCC patients. (c) 2010 Elsevier Ltd. All rights reserved.Entities:
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Year: 2010 PMID： 20138800 DOI： 10.1016/j.oraloncology.2009.12.005
Source DB: PubMed Journal: Oral Oncol ISSN： 1368-8375 Impact factor: 5.337