Literature DB >> 20138521

Development of improved inhibitors of wall teichoic acid biosynthesis with potent activity against Staphylococcus aureus.

Kyungae Lee1, Jennifer Campbell, Jonathan G Swoboda, Gregory D Cuny, Suzanne Walker.   

Abstract

A small molecule (1835F03) that inhibits Staphylococcus aureus wall teichoic acid biosynthesis, a proposed antibiotic target, has been discovered. Rapid, parallel, solution-phase synthesis was employed to generate a focused library of analogs, providing detailed information about structure-activity relationships and leading to the identification of targocil, a potent antibiotic. Copyright 2010 Elsevier Ltd. All rights reserved.

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Year:  2010        PMID： 20138521      PMCID： PMC2844852          DOI： 10.1016/j.bmcl.2010.01.036

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  13 in total

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Review 4.  Linezolid (ZYVOX), the first member of a completely new class of antibacterial agents for treatment of serious gram-positive infections.

Authors:  Steven J Brickner; Michael R Barbachyn; Douglas K Hutchinson; Peter R Manninen
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Review 5.  Current challenges in treating MRSA: what are the options?

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6.  Role of teichoic acids in Staphylococcus aureus nasal colonization, a major risk factor in nosocomial infections.

Authors:  Christopher Weidenmaier; John F Kokai-Kun; Sascha A Kristian; Tanya Chanturiya; Hubert Kalbacher; Matthias Gross; Graeme Nicholson; Birgid Neumeister; James J Mond; Andreas Peschel
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Review 7.  Epidemiology of methicillin-resistant Staphylococcus aureus.

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8.  Discovery of a small molecule that blocks wall teichoic acid biosynthesis in Staphylococcus aureus.

Authors:  Jonathan G Swoboda; Timothy C Meredith; Jennifer Campbell; Stephanie Brown; Takashi Suzuki; Tobias Bollenbach; Amy J Malhowski; Roy Kishony; Michael S Gilmore; Suzanne Walker
Journal:  ACS Chem Biol       Date:  2009-10-16       Impact factor: 5.100

Review 9.  Teichoic acids and related cell-wall glycopolymers in Gram-positive physiology and host interactions.

Authors:  Christopher Weidenmaier; Andreas Peschel
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Review 10.  A continuum of anionic charge: structures and functions of D-alanyl-teichoic acids in gram-positive bacteria.

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  25 in total

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Review 2.  Wall teichoic acids of gram-positive bacteria.

Authors:  Stephanie Brown; John P Santa Maria; Suzanne Walker
Journal:  Annu Rev Microbiol       Date:  2013       Impact factor: 15.500

3.  Exposure of Staphylococcus aureus to Targocil Blocks Translocation of the Major Autolysin Atl across the Membrane, Resulting in a Significant Decrease in Autolysis.

Authors:  Kiran B Tiwari; Craig Gatto; Suzanne Walker; Brian J Wilkinson
Journal:  Antimicrob Agents Chemother       Date:  2018-06-26       Impact factor: 5.191

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Authors:  Kathrin Schirner; Laura K Stone; Suzanne Walker
Journal:  ACS Chem Biol       Date:  2011-02-15       Impact factor: 5.100

5.  In vitro antimicrobial activity of wall teichoic acid biosynthesis inhibitors against Staphylococcus aureus isolates.

Authors:  Takashi Suzuki; Jonathan G Swoboda; Jennifer Campbell; Suzanne Walker; Michael S Gilmore
Journal:  Antimicrob Agents Chemother       Date:  2010-11-22       Impact factor: 5.191

Review 6.  Envelope Structures of Gram-Positive Bacteria.

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7.  Discovery of wall teichoic acid inhibitors as potential anti-MRSA β-lactam combination agents.

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Journal:  Chem Biol       Date:  2013-02-21

8.  Role of wall teichoic acids in Staphylococcus aureus endophthalmitis.

Authors:  Takashi Suzuki; Jennifer Campbell; Jonathan G Swoboda; Suzanne Walker; Michael S Gilmore
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9.  Benzopyrimido-pyrrolo-oxazine-dione CFTR inhibitor (R)-BPO-27 for antisecretory therapy of diarrheas caused by bacterial enterotoxins.

Authors:  Onur Cil; Puay-Wah Phuan; Anne Marie Gillespie; Sujin Lee; Lukmanee Tradtrantip; Jianyi Yin; Ming Tse; Nicholas C Zachos; Ruxian Lin; Mark Donowitz; Alan S Verkman
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10.  Antibiotic That Inhibits the ATPase Activity of an ATP-Binding Cassette Transporter by Binding to a Remote Extracellular Site.

Authors:  Leigh M Matano; Heidi G Morris; Anthony R Hesser; Sara E S Martin; Wonsik Lee; Tristan W Owens; Emaline Laney; Hidemasa Nakaminami; David Hooper; Timothy C Meredith; Suzanne Walker
Journal:  J Am Chem Soc       Date:  2017-07-28       Impact factor: 15.419
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