| Literature DB >> 20138514 |
Michael Arnost1, Al Pierce, Ernst ter Haar, David Lauffer, Jaren Madden, Kirk Tanner, Jeremy Green.
Abstract
A series of 3-aryl-4-(arylhydrazono)-1H-pyrazol-5-one inhibitors of GSK3beta was developed from a low molecular weight, highly ligand efficient screening hit 1. Hit-to-lead optimization led to a number of highly potent inhibitors, while maintaining the high ligand efficiency of the screening hit. Copyright 2010 Elsevier Ltd. All rights reserved.Entities:
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Year: 2010 PMID： 20138514 DOI： 10.1016/j.bmcl.2010.01.072
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823