| Literature DB >> 20138510 |
Marc Gerspacher1, Pascal Furet, Carole Pissot-Soldermann, Christoph Gaul, Philipp Holzer, Eric Vangrevelinghe, Marc Lang, Dirk Erdmann, Thomas Radimerski, Catherine H Regnier, Patrick Chene, Alain De Pover, Francesco Hofmann, Fabienne Baffert, Thomas Buhl, Reiner Aichholz, Francesca Blasco, Ralf Endres, Jörg Trappe, Peter Drueckes.
Abstract
A series of novel benzoxazole derivatives has been designed and shown to exhibit attractive JAK2 inhibitory profiles in biochemical and cellular assays, capable of delivering compounds with favorable PK properties in rats. Synthesis and structure-activity relationship data are also provided. Copyright 2010 Elsevier Ltd. All rights reserved.Entities:
Mesh：
Substances：
Year: 2010 PMID： 20138510 DOI： 10.1016/j.bmcl.2010.01.069
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823