Literature DB >> 20137936

Radiosynthesis of novel carbon-11-labeled triaryl ligands for cannabinoid-type 2 receptor.

Masayuki Fujinaga1, Katsushi Kumata, Kazuhiko Yanamoto, Kazunori Kawamura, Tomoteru Yamasaki, Joji Yui, Akiko Hatori, Masanao Ogawa, Yuichiro Yoshida, Nobuki Nengaki, Jun Maeda, Ming-Rong Zhang.   

Abstract

Two novel triaryl ligands 2 and 5 with potent in vitro binding affinities for the cannabinoid subtype-2 (CB2) receptor were labeled with a positron-emitting radioactive nuclide (11)C. Radioligands [(11)C]2, [(11)C]5, and their analogs [(11)C]3 and [(11)C]4 were synthesized by O-[(11)C]methylation of their corresponding phenol precursors with [(11)C]CH(3)I. [(11)C]2-5 had relatively high uptakes (>1.2% injected dose/g tissue) in mouse brains. Copyright 2010 Elsevier Ltd. All rights reserved.

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Year:  2010        PMID： 20137936     DOI： 10.1016/j.bmcl.2010.01.074

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  6 in total

1.  Amelioration of visual deficits and visual system pathology after mild TBI with the cannabinoid type-2 receptor inverse agonist SMM-189.

Authors:  Natalie M Guley; Nobel A Del Mar; Tyler Ragsdale; Chunyan Li; Aaron M Perry; Bob M Moore; Marcia G Honig; Anton Reiner
Journal:  Exp Eye Res       Date:  2019-03-26       Impact factor: 3.467

2.  Synthesis and biodistribution of [11C]A-836339, a new potential radioligand for PET imaging of cannabinoid type 2 receptors (CB2).

Authors:  Andrew G Horti; Yongjun Gao; Hayden T Ravert; Paige Finley; Heather Valentine; Dean F Wong; Christopher J Endres; Alena V Savonenko; Robert F Dannals
Journal:  Bioorg Med Chem       Date:  2010-05-25       Impact factor: 3.641

3.  Motor, visual and emotional deficits in mice after closed-head mild traumatic brain injury are alleviated by the novel CB2 inverse agonist SMM-189.

Authors:  Anton Reiner; Scott A Heldt; Chaela S Presley; Natalie H Guley; Andrea J Elberger; Yunping Deng; Lauren D'Surney; Joshua T Rogers; Jessica Ferrell; Wei Bu; Nobel Del Mar; Marcia G Honig; Steven N Gurley; Bob M Moore
Journal:  Int J Mol Sci       Date:  2014-12-31       Impact factor: 5.923

4.  Preclinical evaluation of SMM-189, a cannabinoid receptor 2-specific inverse agonist.

Authors:  Chaela Presley; Ammaar Abidi; Satyendra Suryawanshi; Suni Mustafa; Bernd Meibohm; Bob M Moore
Journal:  Pharmacol Res Perspect       Date:  2015-07-06

5.  Mild Traumatic Brain Injury Produces Neuron Loss That Can Be Rescued by Modulating Microglial Activation Using a CB2 Receptor Inverse Agonist.

Authors:  Wei Bu; Huiling Ren; Yunping Deng; Nobel Del Mar; Natalie M Guley; Bob M Moore; Marcia G Honig; Anton Reiner
Journal:  Front Neurosci       Date:  2016-10-06       Impact factor: 4.677

6.  Abnormalities in Dynamic Brain Activity Caused by Mild Traumatic Brain Injury Are Partially Rescued by the Cannabinoid Type-2 Receptor Inverse Agonist SMM-189.

Authors:  Yu Liu; Samuel S McAfee; Natalie M Guley; Nobel Del Mar; Wei Bu; Scott A Heldt; Marcia G Honig; Bob M Moore; Anton Reiner; Detlef H Heck
Journal:  eNeuro       Date:  2017-08-18
  6 in total

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