Literature DB >> 20137930

Absolute configurations of tubulin inhibitors taltobulin (HTI-286) and HTI-042 characterized by X-ray diffraction analysis and NMR studies.

Chuansheng Niu1, Douglas M Ho, Robert Thomas Williamson, Arie Zask, Semiramis Ayral-Kaloustian.   

Abstract

The stereochemistry of the tubulin inhibitors taltobulin HTI-286 (2) and HTI-042 (3) was determined by utilizing the DPFGSE 1D NOE experiment. Single crystal X-ray diffraction analysis further confirmed the absolute configuration of these two compounds, which carry the (S,S,S)-configuration necessary for biological activity. Copyright 2010 Elsevier Ltd. All rights reserved.

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Year:  2010        PMID： 20137930     DOI： 10.1016/j.bmcl.2010.01.047

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  2 in total

1.  Hemiasterlin analogues incorporating an aromatic, and heterocyclic type C-terminus: design, synthesis and biological evaluation.

Authors:  Giordano Lesma; Alessandro Sacchetti; Rouli Bai; Giuseppe Basso; Roberta Bortolozzi; Ernest Hamel; Alessandra Silvani; Nadia Vaiana; Giampietro Viola
Journal:  Mol Divers       Date:  2014-02-06       Impact factor: 2.943

2.  Complementary isonitrile-based multicomponent reactions for the synthesis of diversified cytotoxic hemiasterlin analogues.

Authors:  Giordano Lesma; Ivan Bassanini; Roberta Bortolozzi; Chiara Colletto; Ruoli Bai; Ernest Hamel; Fiorella Meneghetti; Giulia Rainoldi; Mattia Stucchi; Alessandro Sacchetti; Alessandra Silvani; Giampietro Viola
Journal:  Org Biomol Chem       Date:  2015-10-15       Impact factor: 3.876
  2 in total

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