BACKGROUND/ OBJECTIVES: Alterations of voice and speech are frequently observed in Huntington's disease (HD). The aim of this study was to assess the degree of voice and speech abnormalities in a group of patients with HD and to analyze possible correlations with degree of disease severity. PATIENTS/ METHODS: An observational study was carried out on diagnosed cases and controls. The voices of 20 patients were analyzed and compared with an age- and sex-matched control group. Variables analyzed included subjective voice exploration, analysis of aerodynamic efficiency, acoustic analysis measures, and laryngeal examination descriptions. Results obtained were correlated with degree of disease severity. RESULTS: Changes in the Voice Handicap Index and clinical characteristics of the voice were observed. Maximum phonation time was reduced. Acoustic analysis revealed changes that were analyzed. Uncontrolled adduction-abduction movements were observed by laryngeal examination. All results showed a positive correlation with degree of disease severity assessed by the Unified Huntington's Disease Rating Scale. CONCLUSIONS: HD causes alterations in subjective voice features, aerodynamic and acoustic analysis measures that are correlated with disease severity.
BACKGROUND/ OBJECTIVES: Alterations of voice and speech are frequently observed in Huntington's disease (HD). The aim of this study was to assess the degree of voice and speech abnormalities in a group of patients with HD and to analyze possible correlations with degree of disease severity. PATIENTS/ METHODS: An observational study was carried out on diagnosed cases and controls. The voices of 20 patients were analyzed and compared with an age- and sex-matched control group. Variables analyzed included subjective voice exploration, analysis of aerodynamic efficiency, acoustic analysis measures, and laryngeal examination descriptions. Results obtained were correlated with degree of disease severity. RESULTS: Changes in the Voice Handicap Index and clinical characteristics of the voice were observed. Maximum phonation time was reduced. Acoustic analysis revealed changes that were analyzed. Uncontrolled adduction-abduction movements were observed by laryngeal examination. All results showed a positive correlation with degree of disease severity assessed by the Unified Huntington's Disease Rating Scale. CONCLUSIONS:HD causes alterations in subjective voice features, aerodynamic and acoustic analysis measures that are correlated with disease severity.
Authors: Jan Rusz; Jiří Klempíř; Tereza Tykalová; Eva Baborová; Roman Čmejla; Evžen Růžička; Jan Roth Journal: J Neural Transm (Vienna) Date: 2014-05-09 Impact factor: 3.575
Authors: Sarah K Diehl; Antje S Mefferd; Ya-Chen Lin; Jessie Sellers; Katherine E McDonell; Michael de Riesthal; Daniel O Claassen Journal: Neurology Date: 2019-10-29 Impact factor: 9.910
Authors: Jan Rusz; Jiří Klempíř; Eva Baborová; Tereza Tykalová; Veronika Majerová; Roman Cmejla; Evžen Růžička; Jan Roth Journal: PLoS One Date: 2013-06-10 Impact factor: 3.240