Xiao-Qian Liu1, Xin Wang. 1. Department of Hematology, Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, China.
Abstract
OBJECTIVE: To review the recent studies about the role of indoleamine 2,3-dioxygenase (IDO) in tumor induced tolerance. DATA SOURCES: Published articles (1978 - 2009) on IDO and tumor induced tolerance were selected from Medline. STUDY SELECTION: Articles selected were relevant to development of IDO in tumor induced tolerance. Of all originally identified articles, 50 specially addressed the stated purpose. RESULTS: Recent work has revealed IDO at high levels in tumors and in tumor-draining lymph nodes and a close relationship between IDO activity and the regulatory T cells. CONCLUSION: Up-regulation of IDO is proven to be a mechanism of acquired tolerance in tumors, in which the closely coupled positive feedback system between IDO and regulatory T cells may be considered to play an important role.
OBJECTIVE: To review the recent studies about the role of indoleamine 2,3-dioxygenase (IDO) in tumor induced tolerance. DATA SOURCES: Published articles (1978 - 2009) on IDO and tumor induced tolerance were selected from Medline. STUDY SELECTION: Articles selected were relevant to development of IDO in tumor induced tolerance. Of all originally identified articles, 50 specially addressed the stated purpose. RESULTS: Recent work has revealed IDO at high levels in tumors and in tumor-draining lymph nodes and a close relationship between IDO activity and the regulatory T cells. CONCLUSION: Up-regulation of IDO is proven to be a mechanism of acquired tolerance in tumors, in which the closely coupled positive feedback system between IDO and regulatory T cells may be considered to play an important role.
Authors: Silvia K Schmidt; Stephan Siepmann; Katja Kuhlmann; Helmut E Meyer; Sabine Metzger; Sabine Pudelko; Margret Leineweber; Walter Däubener Journal: PLoS One Date: 2012-09-13 Impact factor: 3.240