Jin-Song Liu1, Jun Liu. 1. Division of Gastroenterology, Wuhan Union Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei 430022, China.
Abstract
BACKGROUND: Octride was the main method for the treatment of esophageal variceal bleeding (EVB). The aim of this study was to compare the cost-effect and safety between esophageal variceal ligation (EVL) plus octride and octride alone in acute esophageal bleeding. METHODS: A total of 101 cirrhotic patients with EVB were involved in this study and received emergency EVL + octride (EVL group) or only octride therapy randomly. The cost, efficacy and safety were analyzed and compared between the two groups. RESULTS: Among 51 patients in EVL group, 5 (10%) patients failed. Among 50 patients in the octride treatment group, 13 patients (26%) failed. The difference was significant (P < 0.05). The average blood transfusion volume was (2.4 +/- 2.2) units in the EVL group and (6.4 +/- 3.4) units in the octride treatment group (P < 0.05). Hospital stay was (7.4 +/- 1.3) days in the EVL group and (11.4 +/- 3.3) days in the octride treatment group (P < 0.05). The average hospital cost was (10 983 +/- 1147) yuan in the EVL group and (13 921 +/- 2107) yuan in the octride treatment group (P < 0.05). CONCLUSION: Emergency endoscopic ligation plus octride is superior to octride alone in the treatment of acute EVB with lower cost and higher efficacy with enough safety.
RCT Entities:
BACKGROUND:Octride was the main method for the treatment of esophageal variceal bleeding (EVB). The aim of this study was to compare the cost-effect and safety between esophageal variceal ligation (EVL) plus octride and octride alone in acute esophageal bleeding. METHODS: A total of 101 cirrhotic patients with EVB were involved in this study and received emergency EVL + octride (EVL group) or only octride therapy randomly. The cost, efficacy and safety were analyzed and compared between the two groups. RESULTS: Among 51 patients in EVL group, 5 (10%) patients failed. Among 50 patients in the octride treatment group, 13 patients (26%) failed. The difference was significant (P < 0.05). The average blood transfusion volume was (2.4 +/- 2.2) units in the EVL group and (6.4 +/- 3.4) units in the octride treatment group (P < 0.05). Hospital stay was (7.4 +/- 1.3) days in the EVL group and (11.4 +/- 3.3) days in the octride treatment group (P < 0.05). The average hospital cost was (10 983 +/- 1147) yuan in the EVL group and (13 921 +/- 2107) yuan in the octride treatment group (P < 0.05). CONCLUSION: Emergency endoscopic ligation plus octride is superior to octride alone in the treatment of acute EVB with lower cost and higher efficacy with enough safety.
Authors: Danielle Roberts; Lawrence Mj Best; Suzanne C Freeman; Alex J Sutton; Nicola J Cooper; Sivapatham Arunan; Tanjia Begum; Norman R Williams; Dana Walshaw; Elisabeth Jane Milne; Maxine Tapp; Mario Csenar; Chavdar S Pavlov; Brian R Davidson; Emmanuel Tsochatzis; Kurinchi Selvan Gurusamy Journal: Cochrane Database Syst Rev Date: 2021-04-10
Authors: Fernanda de Quadros Onofrio; Julio Carlos Pereira-Lima; Felipe Marquezi Valença; André Luis Ferreira Azeredo-da-Silva; Airton Tetelbom Stein Journal: Endosc Int Open Date: 2019-10-23