Literature DB >> 20136514

Pomegranate (Punica granatum) seed linolenic acid isomers: concentration-dependent modulation of estrogen receptor activity.

Hoang Ngoc Ai Tran1, Soo-Young Bae, Bang-Ho Song, Bang-Hyo Lee, Young-Seok Bae, Young-Ho Kim, Ephraim Philip Lansky, Robert A Newman.   

Abstract

Pomegranate (Punica granatum) seed linolenic acid isomers were evaluated as selective estrogen receptor modulators (SERMs) in vitro. Punicic acid (PA) inhibited (IC(50)) estrogen receptor (ER) alpha at 7.2 microM, ERbeta at 8.8 microM; alpha-eleostearic acid (AEA) inhibited ERalpha/ERbeta at 6.5/7.8 microM. PA (not AEA) agonized ERalpha/ERbeta (EC(50)) at 1.8/2 microM, antagonizing at 101/80 microM. AEA antagonized ERalpha/ERbeta at 150/140 microM. PA and AEA induced ERalpha and ERbeta mRNA expression in MCF-7, but not in MDA-MB-231. Overall, the results show PA and AEA are SERMs.

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Year:  2010        PMID： 20136514     DOI： 10.3109/07435800903524161

Source DB:  PubMed          Journal:  Endocr Res        ISSN： 0743-5800            Impact factor:   1.720


  8 in total

1.  Pomegranate-mediated chemoprevention of experimental hepatocarcinogenesis involves Nrf2-regulated antioxidant mechanisms.

Authors:  Anupam Bishayee; Deepak Bhatia; Roslin J Thoppil; Altaf S Darvesh; Eviatar Nevo; Ephraim P Lansky
Journal:  Carcinogenesis       Date:  2011-03-09       Impact factor: 4.944

Review 2.  Pomegranate extracts and cancer prevention: molecular and cellular activities.

Authors:  Deeba N Syed; Jean-Christopher Chamcheu; Vaqar M Adhami; Hasan Mukhtar
Journal:  Anticancer Agents Med Chem       Date:  2013-10       Impact factor: 2.505

3.  Improving active and passive avoidance memories deficits due to permanent cerebral ischemia by pomegranate seed extract in female rats.

Authors:  Alireza Sarkaki; Moslem Rezaiei; Mohammadkazem Gharib Naseri; Maryam Rafieirad
Journal:  Malays J Med Sci       Date:  2013-03

4.  Dietary α-eleostearic acid ameliorates experimental inflammatory bowel disease in mice by activating peroxisome proliferator-activated receptor-γ.

Authors:  Stephanie N Lewis; Lera Brannan; Amir J Guri; Pinyi Lu; Raquel Hontecillas; Josep Bassaganya-Riera; David R Bevan
Journal:  PLoS One       Date:  2011-08-31       Impact factor: 3.240

5.  Incorporation and effects of punicic acid on muscle and adipose tissues of rats.

Authors:  Illana Louise Pereira de Melo; Ana Mara de Oliveira e Silva; Eliane Bonifácio Teixeira de Carvalho; Luciana Tedesco Yoshime; José Augusto Gasparotto Sattler; Jorge Mancini-Filho
Journal:  Lipids Health Dis       Date:  2016-02-27       Impact factor: 3.876

Review 6.  Punicic acid: A striking health substance to combat metabolic syndromes in humans.

Authors:  Muhmmad Asim Shabbir; Moazzam Rafiq Khan; Muhammad Saeed; Imran Pasha; Anees Ahmed Khalil; Naila Siraj
Journal:  Lipids Health Dis       Date:  2017-05-30       Impact factor: 3.876

7.  α-linolenic acid and docosahexaenoic acid, alone and combined with trastuzumab, reduce HER2-overexpressing breast cancer cell growth but differentially regulate HER2 signaling pathways.

Authors:  Julie K Mason; Sukhpreet Klaire; Shikhil Kharotia; Ashleigh K A Wiggins; Lilian U Thompson
Journal:  Lipids Health Dis       Date:  2015-08-18       Impact factor: 3.876

8.  The effects of gallic acid on pain and memory following transient global ischemia/reperfusion in Wistar rats.

Authors:  Yaghoob Farbood; Alireza Sarkaki; Sheida Hashemi; Mohammad Taghi Mansouri; Mahin Dianat
Journal:  Avicenna J Phytomed       Date:  2013
  8 in total

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