| Literature DB >> 20136117 |
Hiroyuki Yamakoshi1, Masatoshi Shibuya, Masaki Tomizawa, Yuji Osada, Naoki Kanoh, Yoshiharu Iwabuchi.
Abstract
The first total synthesis of (-)-idesolide was achieved via organocatalytic, enantioselective oxidative kinetic resolution (OKR) using (1S,4S)-4-Bn-1-Bu-AZADOH- and AZADO-catalyzed dimerization of (S)-(-)-methyl 1-hydroxy-6-oxo-2-cyclohexenecarboxylate. The absolute configuration of (-)-idesolide is determined to be 2R,2'S,3aS,7aR.Entities:
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Year: 2010 PMID： 20136117 DOI： 10.1021/ol9029676
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005