Dominik D Alexander1, Meghan E Wagner. 1. Center for Epidemiology, Biostatistics, and Computational Biology, Exponent Inc., Health Sciences, Wood Dale, IL 60191, USA. dalexander@exponent.com
Abstract
OBJECTIVE: To conduct a meta-analysis of studies of benzene exposure and non-Hodgkin lymphoma (NHL). METHODS: A total of 8 cohort and 14 case-control studies were analyzed. RESULTS: Meta-analysis of any benzene exposure resulted in a summary relative risk estimate (SRRE) of 1.02 (95% CI: 0.94 to 1.12). The SRRE changed minimally when only data representing the highest level of benzene exposure were analyzed after an a priori data extraction protocol, using cumulative exposure as the optimum metric (SRRE = 1.08, 95% CI: 0.93 to 1.24). Meta-analysis of five studies that reported results for 60 or more ppm-years of cumulative exposure yielded an SRRE of 1.08 (95% CI: 0.36 to 3.24). Similarly, an SRRE of 1.04 (95% CI: 0.96 to 1.12) for each 25 ppm-year increment of benzene exposure was observed. CONCLUSIONS: The results from this meta-analysis are not supportive of an independent association between benzene exposure and NHL.
OBJECTIVE: To conduct a meta-analysis of studies of benzene exposure and non-Hodgkin lymphoma (NHL). METHODS: A total of 8 cohort and 14 case-control studies were analyzed. RESULTS: Meta-analysis of any benzene exposure resulted in a summary relative risk estimate (SRRE) of 1.02 (95% CI: 0.94 to 1.12). The SRRE changed minimally when only data representing the highest level of benzene exposure were analyzed after an a priori data extraction protocol, using cumulative exposure as the optimum metric (SRRE = 1.08, 95% CI: 0.93 to 1.24). Meta-analysis of five studies that reported results for 60 or more ppm-years of cumulative exposure yielded an SRRE of 1.08 (95% CI: 0.36 to 3.24). Similarly, an SRRE of 1.04 (95% CI: 0.96 to 1.12) for each 25 ppm-year increment of benzene exposure was observed. CONCLUSIONS: The results from this meta-analysis are not supportive of an independent association between benzene exposure and NHL.
Authors: Dominik D Alexander; Xiaohui Jiang; Lauren C Bylsma; David H Garabrant; Sarah R Irvin; Jon P Fryzek Journal: BMJ Open Date: 2014-12-22 Impact factor: 2.692
Authors: A Robert Schnatter; Deborah C Glass; Gong Tang; Richard D Irons; Lesley Rushton Journal: J Natl Cancer Inst Date: 2012-10-30 Impact factor: 13.506