Literature DB >> 20133862

IL-2/anti-IL-2 antibody complexes show strong biological activity by avoiding interaction with IL-2 receptor alpha subunit CD25.

Sven Létourneau1, Ester M M van Leeuwen, Carsten Krieg, Chris Martin, Giuseppe Pantaleo, Jonathan Sprent, Charles D Surh, Onur Boyman.   

Abstract

IL-2 is crucial to T cell homeostasis, especially of CD4(+) T regulatory cells and memory CD8(+) cells, as evidenced by vigorous proliferation of these cells in vivo following injections of superagonist IL-2/anti-IL-2 antibody complexes. The mechanism of IL-2/anti-IL-2 antibody complexes is unknown owing to a lack of understanding of IL-2 homeostasis. We show that IL-2 receptor alpha (CD25) plays a crucial role in IL-2 homeostasis. Thus, prolongation of IL-2 half-life and blocking of CD25 using antibodies or CD25-deficient mice led in combination, but not alone, to vigorous IL-2-mediated T cell proliferation, similar to IL-2/anti-IL-2 antibody complexes. These data suggest an unpredicted role for CD25 in IL-2 homeostasis.

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Year:  2010        PMID： 20133862      PMCID： PMC2836659          DOI： 10.1073/pnas.0909384107

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  46 in total

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3.  IL-7/anti-IL-7 mAb complexes restore T cell development and induce homeostatic T Cell expansion without lymphopenia.

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4.  Specific targeting and killing activities of anti-P-glycoprotein monoclonal antibody MRK16 directed against intrinsically multidrug-resistant human colorectal carcinoma cell lines in the nude mouse model.

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Review 9.  IL-2- and CD25-dependent immunoregulatory mechanisms in the homeostasis of T-cell subsets.

Authors:  Sven Létourneau; Carsten Krieg; Giuseppe Pantaleo; Onur Boyman
Journal:  J Allergy Clin Immunol       Date:  2009-04       Impact factor: 10.793

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  84 in total

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2.  Manipulating Memory CD8 T Cell Numbers by Timed Enhancement of IL-2 Signals.

Authors:  Marie T Kim; Samarchith P Kurup; Gabriel R Starbeck-Miller; John T Harty
Journal:  J Immunol       Date:  2016-07-20       Impact factor: 5.422

3.  Heat shock protein vaccination and directed IL-2 therapy amplify tumor immunity rapidly following bone marrow transplantation in mice.

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4.  Activation and Proliferation of PD-1+ Kidney Double-Negative T Cells Is Dependent on Nonclassical MHC Proteins and IL-2.

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5.  MHC class I and TCR avidity control the CD8 T cell response to IL-15/IL-15Rα complex.

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6.  An artificial antigen-presenting cell with paracrine delivery of IL-2 impacts the magnitude and direction of the T cell response.

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Review 7.  Dynamic Roles for IL-2-STAT5 Signaling in Effector and Regulatory CD4+ T Cell Populations.

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8.  The immunotherapeutic role of regulatory T cells in Leishmania (Viannia) panamensis infection.

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9.  Systemic inflammatory response elicited by superantigen destabilizes T regulatory cells, rendering them ineffective during toxic shock syndrome.

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10.  IL-7/anti-IL-7 mAb complexes augment cytokine potency in mice through association with IgG-Fc and by competition with IL-7R.

Authors:  Christopher E Martin; Ester M M van Leeuwen; Se Jin Im; Derry C Roopenian; Young-Chul Sung; Charles D Surh
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