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Literature DB >> 2013314

Inactivation of human cystatin C and kininogen by human cathepsin D.

B Lenarcic¹, M Krasovec, A Ritonja, I Olafsson, V Turk.

Abstract

A papain inhibitor of 22 kDa was isolated from human placenta and shown to be identical to residues Cys246-Leu373 of the third domain of human kininogen. This kininogen domain and recombinant human cystatin C were inactivated by peptide bond cleavages at hydrophobic amino acid residues due to the action of cathepsin D. These results further support the proposed role of cathepsin D in the regulation of cysteine proteinase activity.

Entities: Chemical Gene Species

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Year: 1991 PMID： 2013314 DOI： 10.1016/0014-5793(91)80295-e

Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124

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Cited

22 in total

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3. Cysteine cathepsins are essential in lysosomal degradation of α-synuclein.

Authors: Ryan P McGlinchey; Jennifer C Lee
Journal: Proc Natl Acad Sci U S A Date: 2015-07-13 Impact factor: 11.205

4. Apolipoprotein A1 and C-terminal fragment of α-1 antichymotrypsin are candidate plasma biomarkers associated with acute renal allograft rejection.

Authors: Mary E Ziegler; Tingchao Chen; James F LeBlanc; Xuelian Wei; David W Gjertson; Ker-Chau Li; Mazdak A Khalighi; Charles R Lassman; Jeffrey L Veale; H Albin Gritsch; Elaine F Reed
Journal: Transplantation Date: 2011-08-27 Impact factor: 4.939

Inactivation of human cystatin C and kininogen by human cathepsin D.

1. Salivary histatin 5 is an inhibitor of both host and bacterial enzymes implicated in periodontal disease.

2. Grassystatins D-F, Potent Aspartic Protease Inhibitors from Marine Cyanobacteria as Potential Antimetastatic Agents Targeting Invasive Breast Cancer.

3. Cysteine cathepsins are essential in lysosomal degradation of α-synuclein.

4. Apolipoprotein A1 and C-terminal fragment of α-1 antichymotrypsin are candidate plasma biomarkers associated with acute renal allograft rejection.

5. Expression of cysteine protease inhibitors in human gliomas and meningiomas.

6. Alpha1-antichymotrypsin and kallistatin hydrolysis by human cathepsin D.

7. Inhibition of human pancreatic proteinases by mucus proteinase inhibitor, eglin c and aprotinin.

Review 8. Cystatin C in aging and in Alzheimer's disease.

9. Hydrogen peroxide induces lysosomal protease alterations in PC12 cells.

Review 10. Cathepsin D--many functions of one aspartic protease.