BACKGROUND: The occurrence of new-onset asthma during adulthood is common, but there is insufficient understanding of its determinants including the role of atopy. OBJECTIVE: To assess the risk factors for the development of new-onset asthma in middle-aged adults and to compare them according to atopy. METHODS: A longitudinal analysis of 9175 young adults who participated in two surveys of the European Community Respiratory Health Survey (ECRHS) conducted 9 years apart. FINDINGS: We observed 179 cases of new-onset asthma among 4588 participants who were free of asthma and reported at the beginning of the follow-up that they had never had asthma (4.5 per 1000 person-years). In a logistic regression, the following risk factors were found to increase the risk of new-onset asthma: female gender (OR: 1.97; 95% confidence interval (CI): 1.38, 2.81), bronchial hyperresponsiveness (3.25; 2.19, 4.83), atopy (1.55; 1.08, 2.21), FEV(1) < 100 % predicted (1.87; 1.34, 2.62), nasal allergy (1.98;1.39,2.84) and maternal asthma (1.91; 1.13; 3.21). Obesity, respiratory infections in early life and high-risk occupations increased the risk of new-onset asthma although we had limited power to confirm their role. Among the atopics, total IgE and sensitization to cat were independently related to the risk of new-onset asthma. The proportion of new-onset asthma attributable to atopy varied from 12% to 21%. CONCLUSION: Adults reporting that they had never had asthma were at a substantial risk of new-onset asthma as a result of multiple independent risk factors including lung function. Atopy explains a small proportion of new-onset adult asthma.
BACKGROUND: The occurrence of new-onset asthma during adulthood is common, but there is insufficient understanding of its determinants including the role of atopy. OBJECTIVE: To assess the risk factors for the development of new-onset asthma in middle-aged adults and to compare them according to atopy. METHODS: A longitudinal analysis of 9175 young adults who participated in two surveys of the European Community Respiratory Health Survey (ECRHS) conducted 9 years apart. FINDINGS: We observed 179 cases of new-onset asthma among 4588 participants who were free of asthma and reported at the beginning of the follow-up that they had never had asthma (4.5 per 1000 person-years). In a logistic regression, the following risk factors were found to increase the risk of new-onset asthma: female gender (OR: 1.97; 95% confidence interval (CI): 1.38, 2.81), bronchial hyperresponsiveness (3.25; 2.19, 4.83), atopy (1.55; 1.08, 2.21), FEV(1) < 100 % predicted (1.87; 1.34, 2.62), nasal allergy (1.98;1.39,2.84) and maternal asthma (1.91; 1.13; 3.21). Obesity, respiratory infections in early life and high-risk occupations increased the risk of new-onset asthma although we had limited power to confirm their role. Among the atopics, total IgE and sensitization to cat were independently related to the risk of new-onset asthma. The proportion of new-onset asthma attributable to atopy varied from 12% to 21%. CONCLUSION: Adults reporting that they had never had asthma were at a substantial risk of new-onset asthma as a result of multiple independent risk factors including lung function. Atopy explains a small proportion of new-onset adult asthma.
Authors: Judith Garcia-Aymerich; Raphaëlle Varraso; Goodarz Danaei; Carlos A Camargo; Miguel A Hernán Journal: Am J Epidemiol Date: 2013-10-09 Impact factor: 4.897
Authors: Jean-Luc Malo; Susan M Tarlo; Joaquin Sastre; James Martin; Mohamed F Jeebhay; Nicole Le Moual; Dick Heederik; Thomas Platts-Mills; Paul D Blanc; Olivier Vandenplas; Gianna Moscato; Frédéric de Blay; André Cartier Journal: Ann Am Thorac Soc Date: 2015-07
Authors: Jordi Alonso; Peter de Jonge; Carmen C W Lim; Sergio Aguilar-Gaxiola; Ronny Bruffaerts; Jose Miguel Caldas-de-Almeida; Zhaorui Liu; Siobhan O'Neill; Dan J Stein; Maria Carmen Viana; Ali Obaid Al-Hamzawi; Matthias C Angermeyer; Guilherme Borges; Marius Ciutan; Giovanni de Girolamo; Fabian Fiestas; Josep Maria Haro; Chiyi Hu; Ronald C Kessler; Jean Pierre Lépine; Daphna Levinson; Yosikazu Nakamura; Jose Posada-Villa; Bogdan J Wojtyniak; Kate M Scott Journal: J Psychiatr Res Date: 2014-09-16 Impact factor: 4.791
Authors: Päivi M Salo; Agustin Calatroni; Peter J Gergen; Jane A Hoppin; Michelle L Sever; Renee Jaramillo; Samuel J Arbes; Darryl C Zeldin Journal: J Allergy Clin Immunol Date: 2011-02-12 Impact factor: 10.793