| Literature DB >> 20132044 |
Weihua Ni1, Xu Zhang, Bo Wang, Yan Chen, Han Han, Yuying Fan, Yifa Zhou, Guihua Tai.
Abstract
A neutral polysaccharide fraction (WGPN) prepared from Panax ginseng C.A. Meyer by hot water extraction and DEAE-cellulose chromatography was tested for its anticancer activity alone and in combination with 5-fluorouracil (5-FU) in Sarcoma-180 (S180) tumor-bearing mice by intragastric administration. WGPN alone inhibited S180 tumor growth in a bell-shaped dose-response curve, and the combination with 5-FU showed a synergistic effect. Studies of various immunological activities in S180-bearing mice revealed that WGPN stimulated the proliferation of lymphocytes, increased natural killer cell cytotoxicity, enhanced the phagocytosis and nitric oxide production by macrophages, and increased the level of tumor necrosis factor-alpha in serum. In combination with 5-FU, WGPN mitigated damage to the immune system caused by 5-FU in S180-bearing mice. These results suggest that WGPN might be a potential adjuvant for chemotherapeutic drugs.Entities:
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Year: 2010 PMID： 20132044 DOI： 10.1089/jmf.2009.1119
Source DB: PubMed Journal: J Med Food ISSN： 1096-620X Impact factor: 2.786