Literature DB >> 20131102

Primary mediastinal (thymic) large B cell lymphoma with aberrant expression of CD3: a case report with review of the literature.

Endi Wang1, Maggie Stoecker.   

Abstract

We report the first case of primary mediastinal large B cell lymphoma (PMBL) with aberrant expression of CD3. PMBL is a subtype of diffuse large B cell lymphoma (DLBCL) and usually presents with bulky mediastinal lesions. Lineage ambiguity/infidelity is uncommon in DLBCL but has been described in sporadic case reports/series. A literature search identifies 13 additional cases of DLBCL expressing CD3, with the majority displaying cytoplasmic expression. Of the 14 total cases, 6 are pyothorax-associated lymphoma, 4 are conventional DLBCL, 2 are plasmablastic lymphoma, one is primary effusion lymphoma and one is PMBL. Two cases show genotypic ambiguity/infidelity with dual clonal IG and TCR gene rearrangements in addition to ambiguous immunophenotypes. Of the 13 cases tested for EBV status, 11 are positive, suggesting an important role of EBV in promoting lineage ambiguity/infidelity. A low threshold for testing EBV status is advocated in DLBCL with phenotypic ambiguity along with panels of immunohistochemical and molecular studies.

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Year:  2010        PMID： 20131102     DOI： 10.1007/s12185-010-0501-4

Source DB:  PubMed          Journal:  Int J Hematol        ISSN： 0925-5710            Impact factor:   2.490


  14 in total

1.  A biophenotypic human herpesvirus 8--associated primary bowel lymphoma.

Authors:  M W Beaty; S Kumar; L Sorbara; K Miller; M Raffeld; E S Jaffe
Journal:  Am J Surg Pathol       Date:  1999-08       Impact factor: 6.394

Review 2.  Mediastinal (thymic) large B-cell lymphoma: where do we stand?

Authors:  Thomas F E Barth; Frank Leithäuser; Stefan Joos; Martin Bentz; Peter Möller
Journal:  Lancet Oncol       Date:  2002-04       Impact factor: 41.316

3.  Immunoglobulin and T-cell receptor gene rearrangements: minding your B's and T's in assessing lineage and clonality in neoplastic lymphoproliferative disorders.

Authors:  Adam Bagg
Journal:  J Mol Diagn       Date:  2006-09       Impact factor: 5.568

4.  Pyothorax-associated lymphoma. An unusual case with biphenotypic character of T and B cells.

Authors:  N Mori; Y Yatabe; M Narita; T Kobayashi; J Asai
Journal:  Am J Surg Pathol       Date:  1996-06       Impact factor: 6.394

Review 5.  Definition of acute biphenotypic leukemia.

Authors:  E Matutes; R Morilla; N Farahat; F Carbonell; J Swansbury; M Dyer; D Catovsky
Journal:  Haematologica       Date:  1997 Jan-Feb       Impact factor: 9.941

6.  Pyothorax-associated lymphoma: a peculiar clinicopathologic entity derived from B cells at late stage of differentiation and with occasional aberrant dual B- and T-cell phenotype.

Authors:  Bruno Petitjean; Fabrice Jardin; Bertrand Joly; Nadine Martin-Garcia; Hervé Tilly; Jean-Michel Picquenot; Josette Brière; Claire Danel; Sylvie Mehaut; Issam Abd-Al-Samad; Christiane Copie-Bergman; Marie-Hélène Delfau-Larue; Philippe Gaulard
Journal:  Am J Surg Pathol       Date:  2002-06       Impact factor: 6.394

7.  CD43 expression is an adverse prognostic factor in diffuse large B-Cell lymphoma.

Authors:  Zdravko Mitrovic; Ivana Ilic; Marin Nola; Igor Aurer; Zdenko Sonicki; Sandra Basic-Kinda; Ivo Radman; Radmila Ajdukovic; Boris Labar
Journal:  Clin Lymphoma Myeloma       Date:  2009-04

8.  Immunodeficiency-associated malignant lymphoma. Three cases showing genotypic evidence of both T- and B-cell lineages.

Authors:  H C Hollingsworth; M Stetler-Stevenson; D Gagneten; D W Kingma; M Raffeld; E S Jaffe
Journal:  Am J Surg Pathol       Date:  1994-11       Impact factor: 6.394

9.  A novel human lymphoma cell line (Deglis) with dual B/T phenotype and gene rearrangements and containing Epstein-Barr virus genomes.

Authors:  T al Saati; H J Delécluze; S Chittal; P Brousset; J P Magaud; N Dastugue; E Cohen-Knafo; G Laurent; B Rubin; G Delsol
Journal:  Blood       Date:  1992-07-01       Impact factor: 22.113

Review 10.  Diffuse large B-cell lymphoma with coexpression of CD3 in a pediatric patient: a case report, review of the literature, and tissue microarray study.

Authors:  Jeremy C Wallentine; Sherrie L Perkins; Sheryl R Tripp; Richard D Bruggman; Michael G Bayerl
Journal:  J Pediatr Hematol Oncol       Date:  2009-02       Impact factor: 1.289
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  5 in total

1.  CD4-positive diffuse large B cell lymphoma identified by flow cytometry: two case reports.

Authors:  Marisa Arrondini; Antonella Barreca; Sabrina Aliberti; Anna Demurtas; Fabrizio Tondat; Domenico Novero; Alessandra Stacchini
Journal:  Int J Hematol       Date:  2010-06-25       Impact factor: 2.490

2.  CD3-positive plasmablastic B-cell neoplasms: a diagnostic pitfall.

Authors:  Zenggang Pan; Mingyi Chen; Qianyun Zhang; Endi Wang; Liqun Yin; Youyuan Xu; Qin Huang; Youzhong Yuan; Xiaohui Zhang; Gang Zheng; Ji Yuan
Journal:  Mod Pathol       Date:  2018-01-12       Impact factor: 7.842

3.  Primary Mediastinal Large B-cell Lymphoma Exhibiting Endobronchial Involvement.

Authors:  Midori Shimada; Minoru Fukuda; Kensuke Horio; Takayuki Suyama; Takeshi Kitazaki; Kohji Hashiguchi; Masaaki Fukuda; Kazuto Shigematsu; Yoichi Nakamura; Takuya Honda; Kazuto Ashizawa; Hiroshi Mukae
Journal:  Intern Med       Date:  2016-11-01       Impact factor: 1.271

4.  Clinical and prognostic significance of aberrant T-cell marker expression in 225 cases of de novo diffuse large B-cell lymphoma and 276 cases of other B-cell lymphomas.

Authors:  Naoko Tsuyama; Daisuke Ennishi; Masahiro Yokoyama; Satoko Baba; Reimi Asaka; Yuko Mishima; Yasuhito Terui; Kiyohiko Hatake; Kengo Takeuchi
Journal:  Oncotarget       Date:  2017-05-16

5.  Langerhans cell sarcoma with an aberrant cytoplasmic CD3 expression.

Authors:  Zhaodong Xu; Ruth Padmore; Carolyn Faught; Lisa Duffet; Bruce F Burns
Journal:  Diagn Pathol       Date:  2012-09-25       Impact factor: 2.644
  5 in total

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