Literature DB >> 20130572

Substrate check of gamma-secretase.

Yun-wu Zhang, Huaxi Xu.   

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Year:  2010        PMID： 20130572     DOI： 10.1038/nsmb0210-140

Source DB:  PubMed          Journal:  Nat Struct Mol Biol        ISSN： 1545-9985            Impact factor:   15.369


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  11 in total

1.  A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity.

Authors:  S Weggen; J L Eriksen; P Das; S A Sagi; R Wang; C U Pietrzik; K A Findlay; T E Smith; M P Murphy; T Bulter; D E Kang; N Marquez-Sterling; T E Golde; E H Koo
Journal:  Nature       Date:  2001-11-08       Impact factor: 49.962

2.  Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells.

Authors:  Johan H van Es; Marielle E van Gijn; Orbicia Riccio; Maaike van den Born; Marc Vooijs; Harry Begthel; Miranda Cozijnsen; Sylvie Robine; Doug J Winton; Freddy Radtke; Hans Clevers
Journal:  Nature       Date:  2005-06-16       Impact factor: 49.962

3.  TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity.

Authors:  Fusheng Chen; Hiroshi Hasegawa; Gerold Schmitt-Ulms; Toshitaka Kawarai; Christopher Bohm; Taiichi Katayama; Yongjun Gu; Nobuo Sanjo; Michael Glista; Ekaterina Rogaeva; Yosuke Wakutani; Raphaëlle Pardossi-Piquard; Xueying Ruan; Anurag Tandon; Frédéric Checler; Philippe Marambaud; Kirk Hansen; David Westaway; Peter St George-Hyslop; Paul Fraser
Journal:  Nature       Date:  2006-04-27       Impact factor: 49.962

4.  Modulation of gamma-secretase specificity using small molecule allosteric inhibitors.

Authors:  Christopher C Shelton; Lei Zhu; Deming Chau; Li Yang; Rong Wang; Hakim Djaballah; Hui Zheng; Yue-Ming Li
Journal:  Proc Natl Acad Sci U S A       Date:  2009-11-11       Impact factor: 11.205

5.  Reconstitution of gamma-secretase activity.

Authors:  Dieter Edbauer; Edith Winkler; Joerg T Regula; Brigitte Pesold; Harald Steiner; Christian Haass
Journal:  Nat Cell Biol       Date:  2003-05       Impact factor: 28.824

6.  Nicastrin functions as a gamma-secretase-substrate receptor.

Authors:  Sanjiv Shah; Sheu-Fen Lee; Katsuhiko Tabuchi; Yi-Heng Hao; Cong Yu; Quincey LaPlant; Haydn Ball; Charles E Dann; Thomas Südhof; Gang Yu
Journal:  Cell       Date:  2005-08-12       Impact factor: 41.582

7.  CD147 is a regulatory subunit of the gamma-secretase complex in Alzheimer's disease amyloid beta-peptide production.

Authors:  Shuxia Zhou; Hua Zhou; Peter J Walian; Bing K Jap
Journal:  Proc Natl Acad Sci U S A       Date:  2005-05-12       Impact factor: 11.205

Review 8.  The gamma-secretase complex: machinery for intramembrane proteolysis.

Authors:  Takeshi Iwatsubo
Journal:  Curr Opin Neurobiol       Date:  2004-06       Impact factor: 6.627

9.  An APP inhibitory domain containing the Flemish mutation residue modulates gamma-secretase activity for Abeta production.

Authors:  Yuan Tian; Bhramdeo Bassit; Deming Chau; Yue-Ming Li
Journal:  Nat Struct Mol Biol       Date:  2010-01-10       Impact factor: 15.369

10.  Discovery of begacestat, a Notch-1-sparing gamma-secretase inhibitor for the treatment of Alzheimer's disease.

Authors:  Scott C Mayer; Anthony F Kreft; Boyd Harrison; Magid Abou-Gharbia; Madelene Antane; Suzan Aschmies; Kevin Atchison; Michael Chlenov; Derek C Cole; Thomas Comery; George Diamantidis; John Ellingboe; Kristi Fan; Rocco Galante; Cathleen Gonzales; Douglas M Ho; Molly E Hoke; Yun Hu; Donna Huryn; Uday Jain; Mei Jin; Kenneth Kremer; Dennis Kubrak; Melissa Lin; Peimin Lu; Ron Magolda; Robert Martone; William Moore; Aram Oganesian; Menelas N Pangalos; Alex Porte; Peter Reinhart; Lynn Resnick; David R Riddell; June Sonnenberg-Reines; Joseph R Stock; Shaiu-Ching Sun; Erik Wagner; Ting Wang; Kevin Woller; Zheng Xu; Margaret M Zaleska; Joseph Zeldis; Minsheng Zhang; Hua Zhou; J Steven Jacobsen
Journal:  J Med Chem       Date:  2008-12-11       Impact factor: 7.446
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  1 in total

Review 1.  Complex regulation of γ-secretase: from obligatory to modulatory subunits.

Authors:  Natalya Gertsik; Danica Chiu; Yue-Ming Li
Journal:  Front Aging Neurosci       Date:  2015-01-06       Impact factor: 5.750
  1 in total

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