OBJECTIVE: To evaluate bone mineral density (BMD) and bone metabolism in hypertensive postmenopausal women, and to differentiate the effect of thiazides from that of other antihypertensive agents. SUBJECTS AND METHODS: A community-based population of 636 postmenopausal women, 293 with hypertension (160 receiving thiazides, and 133 receiving other antihypertensive treatments), and 343 control women, were evaluated. Serum levels of aminoterminal propeptide of type I collagen (P1NP), C-terminal telopeptide of type I collagen (beta-CTX), 25-hydroxivitamin D, and intact parathyroid hormone were measured by electrochemiluminiscence. BMD was determined by DXA, and heel quantitative ultrasound measurements (QUS) with a gel-coupled device. RESULTS: BMD expressed as Z-score was higher in both groups of hypertensive women at all locations. Expressed as g/cm(2), it was also higher in patients on thiazides at femoral neck and lumbar spine. Only in the latter site, differences remained significant after adjusting for potential confounding variables, including BMI. Bone turnover markers were lower in both groups of hypertensive women, although the difference was greater in those on thiazides. After adjusting for potential confounders, differences remained significant only in the thiazide group. CONCLUSIONS: Our results add evidence to the idea that thiazides are beneficial to prevent bone loss. Copyright 2010 Elsevier Ireland Ltd. All rights reserved.
OBJECTIVE: To evaluate bone mineral density (BMD) and bone metabolism in hypertensive postmenopausal women, and to differentiate the effect of thiazides from that of other antihypertensive agents. SUBJECTS AND METHODS: A community-based population of 636 postmenopausal women, 293 with hypertension (160 receiving thiazides, and 133 receiving other antihypertensive treatments), and 343 control women, were evaluated. Serum levels of aminoterminal propeptide of type I collagen (P1NP), C-terminal telopeptide of type I collagen (beta-CTX), 25-hydroxivitamin D, and intact parathyroid hormone were measured by electrochemiluminiscence. BMD was determined by DXA, and heel quantitative ultrasound measurements (QUS) with a gel-coupled device. RESULTS: BMD expressed as Z-score was higher in both groups of hypertensivewomen at all locations. Expressed as g/cm(2), it was also higher in patients on thiazides at femoral neck and lumbar spine. Only in the latter site, differences remained significant after adjusting for potential confounding variables, including BMI. Bone turnover markers were lower in both groups of hypertensivewomen, although the difference was greater in those on thiazides. After adjusting for potential confounders, differences remained significant only in the thiazide group. CONCLUSIONS: Our results add evidence to the idea that thiazides are beneficial to prevent bone loss. Copyright 2010 Elsevier Ireland Ltd. All rights reserved.
Authors: Emilio Pariente; José M Olmos; Rosa Landeras; Daniel Nan; Jesús González-Macías; José Luis Hernández Journal: J Bone Miner Metab Date: 2016-01-29 Impact factor: 2.626
Authors: Beatriz Tejera-Segura; Raquel López-Mejías; María Jesús Domínguez-Luis; Antonia M de Vera-González; Alejandra González-Delgado; Begoña Ubilla; José M Olmos; José L Hernández; Miguel A González-Gay; Iván Ferraz-Amaro Journal: Arthritis Res Ther Date: 2017-10-17 Impact factor: 5.156
Authors: Beatriz Tejera-Segura; María Macía-Díaz; José David Machado; Antonia de Vera-González; Jose A García-Dopico; José M Olmos; José L Hernández; Federico Díaz-González; Miguel A González-Gay; Iván Ferraz-Amaro Journal: Arthritis Res Ther Date: 2017-05-31 Impact factor: 5.156