Jian-Hua Wang1, Jin Zhao, Jun Lin. 1. Department of Gynecology, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
Abstract
STUDY OBJECTIVE: To estimate the prevalence of benign, premalignant, and malignant endometrial polyps and the associated clinical risk factors for premalignant and malignant endometrial polyps. DESIGN: Retrospective study (Canadian Classification II-3). SETTING: Teaching hospital. PATIENTS: Seven hundred sixty-six patients with endometrial polyps. INTERVENTIONS: Hysteroscopic removal of endometrial polyps. MEASUREMENTS AND MAIN RESULTS: Patient clinical data were identified and analyzed. Frequency of premalignant and malignant histopathologic features in endometrial polyps was calculated. Clinical risk factors for premalignant and malignant endometrial polyps were analyzed. Endometrial polyps were histologically benign in most patients (96.21%). Hyperplasia with atypia in a polyp (premalignant polyp) was found in 3.26% of patients, and endometrial carcinoma in a polyp (malignant polyp) was detected in only 0.52% of patients. Independent variables that were significantly related to premalignant and malignant polyps (all p<.05) in a binary logistic regression analysis included polyp diameter (odds ratio [OR], 2.93; 95% confidence interval [CI], 1.191-7.20), menopause status (OR, 4.85; 95% CI, 2.09-11.27), and abnormal uterine bleeding (OR, 3.97; 95% CI, 1.71-9.18). CONCLUSION: Polyp diameter larger than 1.0cm, menopause status, and abnormal uterine bleeding may increase the risk of premalignant and malignant endometrial polyps. Copyright (c) 2010 AAGL. Published by Elsevier Inc. All rights reserved.
STUDY OBJECTIVE: To estimate the prevalence of benign, premalignant, and malignant endometrial polyps and the associated clinical risk factors for premalignant and malignant endometrial polyps. DESIGN: Retrospective study (Canadian Classification II-3). SETTING: Teaching hospital. PATIENTS: Seven hundred sixty-six patients with endometrial polyps. INTERVENTIONS: Hysteroscopic removal of endometrial polyps. MEASUREMENTS AND MAIN RESULTS:Patient clinical data were identified and analyzed. Frequency of premalignant and malignant histopathologic features in endometrial polyps was calculated. Clinical risk factors for premalignant and malignant endometrial polyps were analyzed. Endometrial polyps were histologically benign in most patients (96.21%). Hyperplasia with atypia in a polyp (premalignant polyp) was found in 3.26% of patients, and endometrial carcinoma in a polyp (malignant polyp) was detected in only 0.52% of patients. Independent variables that were significantly related to premalignant and malignant polyps (all p<.05) in a binary logistic regression analysis included polyp diameter (odds ratio [OR], 2.93; 95% confidence interval [CI], 1.191-7.20), menopause status (OR, 4.85; 95% CI, 2.09-11.27), and abnormal uterine bleeding (OR, 3.97; 95% CI, 1.71-9.18). CONCLUSION: Polyp diameter larger than 1.0cm, menopause status, and abnormal uterine bleeding may increase the risk of premalignant and malignant endometrial polyps. Copyright (c) 2010 AAGL. Published by Elsevier Inc. All rights reserved.
Authors: Andrea Ciavattini; Jacopo DI Giuseppe; Nicolò Clemente; Lorenzo Moriconi; Giovanni Delli Carpini; Nina Montik; Laura Mazzanti Journal: Oncol Lett Date: 2016-02-04 Impact factor: 2.967
Authors: Marco Antonio Lenci; Vanessa Alessandra Lui do Nascimento; Ana Beatriz Grandini; Walid Makin Fahmy; Daniella de Batista Depes; Fausto Farah Baracat; Reginaldo Guedes Coelho Lopes Journal: Einstein (Sao Paulo) Date: 2014 Jan-Mar