BACKGROUND: There has been limited research on sleep quality (SQ) in CKD. METHODS: This prospective cohort study of adults with CKD Stages 3 - 5 at four US centers collected self-reported SQ information from the Kidney Disease Quality of Life (KDQOL) instrument, including an estimated SQ score (0 - 100), and 3 SQ-related questions. "Poor" SQ was defined as SQ score < or = 60. Logistic and multiple linear regression assessed associations between SQ and its potential predictors. Times to death and end stage renal disease (ESRD) were examined using Cox regression. A comparison with SQ in ESRD patients from the Dialysis Outcomes and Practice Patterns Study (DOPPS), was additionally performed. RESULTS: Mean SQ score was 59.4 +/- 23.6 (n = 689), and "poor" SQ was reported by 57%. Mean estimated glomerular filtration rate (eGFR) was 24.9 +/- 10.6 ml/min/1.73 m2. Higher SQ significantly correlated with KDQOL mental and physical component summary scales. Significant predictors of lower SQ score included--younger age, presence of dyspnea, self-reported depression, pain, and itchness. There were no significant pairwise differences in SQ from CKD Stage 3 through ESRD. Self-reported daytime sleepiness was significantly associated with higher risk of mortality prior to ESRD (HR = 1.85, p = 0.02). CONCLUSION: Self-reported "poor" SQ was common in a CKD cohort (Stages 3 - 5) and was not only associated with lower quality of life scores and several modifiable symptoms, but also with higher risk of pre-ESRD mortality. Greater attention to this clinical problem is highly recommended in this high-risk population.
BACKGROUND: There has been limited research on sleep quality (SQ) in CKD. METHODS: This prospective cohort study of adults with CKD Stages 3 - 5 at four US centers collected self-reported SQ information from the Kidney Disease Quality of Life (KDQOL) instrument, including an estimated SQ score (0 - 100), and 3 SQ-related questions. "Poor" SQ was defined as SQ score < or = 60. Logistic and multiple linear regression assessed associations between SQ and its potential predictors. Times to death and end stage renal disease (ESRD) were examined using Cox regression. A comparison with SQ in ESRDpatients from the Dialysis Outcomes and Practice Patterns Study (DOPPS), was additionally performed. RESULTS: Mean SQ score was 59.4 +/- 23.6 (n = 689), and "poor" SQ was reported by 57%. Mean estimated glomerular filtration rate (eGFR) was 24.9 +/- 10.6 ml/min/1.73 m2. Higher SQ significantly correlated with KDQOL mental and physical component summary scales. Significant predictors of lower SQ score included--younger age, presence of dyspnea, self-reported depression, pain, and itchness. There were no significant pairwise differences in SQ from CKD Stage 3 through ESRD. Self-reported daytime sleepiness was significantly associated with higher risk of mortality prior to ESRD (HR = 1.85, p = 0.02). CONCLUSION: Self-reported "poor" SQ was common in a CKD cohort (Stages 3 - 5) and was not only associated with lower quality of life scores and several modifiable symptoms, but also with higher risk of pre-ESRD mortality. Greater attention to this clinical problem is highly recommended in this high-risk population.
Authors: Barbara Riegel; Alexandra L Hanlon; Xuemei Zhang; Desiree Fleck; Steven L Sayers; Lee R Goldberg; William S Weintraub Journal: J Am Assoc Nurse Pract Date: 2012-09-24 Impact factor: 1.165
Authors: Oreste Marrone; Fabio Cibella; Gabriel Roisman; Pawel Sliwinski; Pavol Joppa; Ozen K Basoglu; Izolde Bouloukaki; Sophia Schiza; Athanasia Pataka; Richard Staats; Johan Verbraecken; Jan Hedner; Ludger Grote; Maria R Bonsignore Journal: J Clin Sleep Med Date: 2020-09-15 Impact factor: 4.062
Authors: Ira D Davis; Larry A Greenbaum; Debbie Gipson; Lie Ling Wu; Rajiv Sinha; Mina Matsuda-Abedini; Judith L Emancipator; Jerome C Lane; Kavita Hodgkins; Corina Nailescu; Gina Marie Barletta; Steven Arora; John D Mahan; Carol L Rosen Journal: Pediatr Nephrol Date: 2011-10-02 Impact factor: 3.714
Authors: Hanna Burkhalter; Daniel P Brunner; Anna Wirz-Justice; Christian Cajochen; Terri E Weaver; Jürg Steiger; Thomas Fehr; Reto M Venzin; Sabina De Geest Journal: BMC Nephrol Date: 2013-10-10 Impact factor: 2.388