Literature DB >> 20127427

Effect of formulation parameters on the preparation of superporous hydrogel self-nanoemulsifying drug delivery system (SNEDDS) of carvedilol.

Enas Ahmed Mahmoud1, Ehab R Bendas, Magdy I Mohamed.   

Abstract

The purpose of this study was to formulate a superporous hydrogel (SPH) containing carvedilol self-nanoemulsifying drug delivery system. Effects of formulation parameters (amount of SPH and 0.1 N HCl used during drug loading) were studied in 3(2) factorial design. Response surface plots showed significant effect of the parameters on hydrogel swelling, carvedilol content, and carvedilol in vitro release. Regression equations were generated to calculate the desirable responses.

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Year:  2010        PMID： 20127427      PMCID： PMC2850453          DOI： 10.1208/s12249-009-9359-2

Source DB:  PubMed          Journal:  AAPS PharmSciTech        ISSN： 1530-9932            Impact factor:   3.246


  7 in total

1.  Synthesis of superporous hydrogels: hydrogels with fast swelling and superabsorbent properties.

Authors:  J Chen; H Park; K Park
Journal:  J Biomed Mater Res       Date:  1999-01

2.  Synthesis and characterization of superporous hydrogel composites.

Authors:  J Chen; K Park
Journal:  J Control Release       Date:  2000-03-01       Impact factor: 9.776

3.  Superporous IPN hydrogels having enhanced mechanical properties.

Authors:  Yong Qiu; Kinam Park
Journal:  AAPS PharmSciTech       Date:  2003-10-13       Impact factor: 3.246

4.  A new hydrogel for the extended and complete prednisolone release in the GI tract.

Authors:  G Di Colo; A Baggiani; Y Zambito; G Mollica; M Geppi; M F Serafini
Journal:  Int J Pharm       Date:  2006-01-18       Impact factor: 5.875

5.  Functional polymer hydrogels for embryonic stem cell support.

Authors:  Jana Kroupová; Daniel Horák; Jirí Pacherník; Petr Dvorák; Miroslav Slouf
Journal:  J Biomed Mater Res B Appl Biomater       Date:  2006-02       Impact factor: 3.368

6.  Elastic, superporous hydrogel hybrids of polyacrylamide and sodium alginate.

Authors:  Hossein Omidian; Jose G Rocca; Kinam Park
Journal:  Macromol Biosci       Date:  2006-09-15       Impact factor: 4.979

7.  Transport of octreotide and evaluation of mechanism of opening the paracellular tight junctions using superporous hydrogel polymers in Caco-2 cell monolayers.

Authors:  Farid A Dorkoosh; Corine A N Broekhuizen; Gerrit Borchard; Morteza Rafiee-Tehrani; J Coos Verhoef; Hans E Junginger
Journal:  J Pharm Sci       Date:  2004-03       Impact factor: 3.534
  7 in total
  1 in total

1.  Developing micro-/nanoparticulate drug delivery systems using "design of experiments".

Authors:  Bhupinder Singh; Rahul Bhatowa; Chandra Bhushan Tripathi; Rishi Kapil
Journal:  Int J Pharm Investig       Date:  2011-04
  1 in total

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