OBJECTIVE: In cancer patients, the balance between neutrophil (N) and lymphocyte (L) cell counts fluctuates with advancing disease. The objective of our study was to determine the prognostic implications of the N/L ratio in the peripheral blood of rectal cancer patients. METHODS: Study participants were identified from a prospective cohort of patients with rectal cancer in Dalian of China (n = 123). RESULTS: The median baseline N/L ratio was 2.41 +/- 2.206 (range, 0.76-20.45). Our results revealed that the N/L ratio was significantly associated with tumor size (P = 0.003) and level of cancer antigen 125 (P = 0.027). A multivariate Cox model established a significant relationship between the N/L ratio and survival (adjusted hazard ratio, 2.615; 95% confidence interval, 1.152-5.933; P = 0.021). CONCLUSIONS: These results suggest that the N/L ratio is an independent prognostic factor in rectal cancer, and the N/L ratio may serve as a clinically accessible and useful biomarker for patient survival.
OBJECTIVE: In cancerpatients, the balance between neutrophil (N) and lymphocyte (L) cell counts fluctuates with advancing disease. The objective of our study was to determine the prognostic implications of the N/L ratio in the peripheral blood of rectal cancerpatients. METHODS: Study participants were identified from a prospective cohort of patients with rectal cancer in Dalian of China (n = 123). RESULTS: The median baseline N/L ratio was 2.41 +/- 2.206 (range, 0.76-20.45). Our results revealed that the N/L ratio was significantly associated with tumor size (P = 0.003) and level of cancer antigen 125 (P = 0.027). A multivariate Cox model established a significant relationship between the N/L ratio and survival (adjusted hazard ratio, 2.615; 95% confidence interval, 1.152-5.933; P = 0.021). CONCLUSIONS: These results suggest that the N/L ratio is an independent prognostic factor in rectal cancer, and the N/L ratio may serve as a clinically accessible and useful biomarker for patient survival.
Authors: S Suzuki; S Toyabe; T Moroda; T Tada; A Tsukahara; T Iiai; M Minagawa; S Maruyama; K Hatakeyama; K Endoh; T Abo Journal: Clin Exp Immunol Date: 1997-12 Impact factor: 4.330
Authors: Asaf Spiegel; Mary W Brooks; Samin Houshyar; Ferenc Reinhardt; Michele Ardolino; Evelyn Fessler; Michelle B Chen; Jordan A Krall; Jasmine DeCock; Ioannis K Zervantonakis; Alexandre Iannello; Yoshiko Iwamoto; Virna Cortez-Retamozo; Roger D Kamm; Mikael J Pittet; David H Raulet; Robert A Weinberg Journal: Cancer Discov Date: 2016-04-12 Impact factor: 39.397
Authors: Douglas D Benson; Marguerite R Kelher; Xianzhong Meng; David A Fullerton; Joon H Lee; Christopher C Silliman; Carlton C Barnett Journal: J Gastrointest Surg Date: 2010-09-11 Impact factor: 3.452
Authors: Georgina Wood; Tal Grenader; Stephen Nash; Richard Adams; Richard Kaplan; David Fisher; Tim Maughan; John Bridgewater Journal: Anticancer Drugs Date: 2017-06 Impact factor: 2.248