| Literature DB >> 20127208 |
Irena Djunic1, Ivo Elezovic, Milica Marinkovic, Nada Suvajdzic-Vukovic, Dragica Tomin, Gradimir Jankovic, Jelena Bila, Darko Antic, Ana Vidovic, Borka Neskovic, Dragica Nikolic-Vukosavljevic.
Abstract
The degradation product of collagen type I carboxy terminal telopeptide (ICTP) represents a new biochemical parameter that reflects the changes in the resorption properties of skeletal system. Affection of the skeleton is one of the most important characteristics of multiple myeloma (MM). We estimated significance of ICTP as osteolysis predictor and overall survival in comparison with standard prognostic parameters β(2)-microglobulin and C-reactive protein (CRP), in patients with MM. With our results, we have shown significant difference in serum level of ICTP (P = 0.009) between patients with and without osteolysis on conventional radiography. It was proved that ICTP is the most significant predictor of osteolysis (P = 0.09), while CRP is the most significant risk factor for overall survival (P < 0.01). Being highly significant predictor of osteolysis, ICTP can be used for identification of patients with MM who had increased risk for developing osteolytic lesions.Entities:
Mesh：
Substances：
Year: 2010 PMID： 20127208 DOI： 10.1007/s12032-010-9432-4
Source DB: PubMed Journal: Med Oncol ISSN： 1357-0560 Impact factor: 3.064