Literature DB >> 20127180

Impact of ERCC2 gene polymorphism on HIV-1 disease progression to AIDS among North Indian HIV patients.

Ranbir Chander Sobti1, Nega Berhane, Salih Abdul Mahdi, Rupinder Kler, Seyed Ali Hosseini, Vijish Kuttiat, Ajay Wanchu.   

Abstract

HIV/AIDS remains to be one of the killing diseases of mankind. Host genetic response is one of the factor which determine susceptibility to HIV and disease progression to AIDS. The aim of the present study was to evaluate the impact of ERCC2 Lyc ( 751 ) Gln (excision repair cross complementing rodent repair deficiency, complementation group 2) polymorphism on HIV-1 susceptibility and disease progression to AIDS, as this gene has been reported to intervene in degrading retroviral cDNA before it integrates with the host DNA. This case control study included 300 HIV seropositive cases and an equal number of HIV seronegative controls. DNA was isolated from the blood samples of study subjects and genotyping of ERCC2 was conducted by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) method. The Gln/Gln genotype showed a significant variation between cases and controls (P = 0.047, OR 1.71, 95% CI 1.00-2.93), indicating a possible role of susceptibility in reference to controls and disease progression when compared within cases.

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Year:  2010        PMID： 20127180     DOI： 10.1007/s11033-010-9958-8

Source DB:  PubMed          Journal:  Mol Biol Rep        ISSN： 0301-4851            Impact factor:   2.316


  43 in total

1.  The coreceptor mutation CCR5Delta32 influences the dynamics of HIV epidemics and is selected for by HIV.

Authors:  A D Sullivan; J Wigginton; D Kirschner
Journal:  Proc Natl Acad Sci U S A       Date:  2001-08-21       Impact factor: 11.205

2.  ERCC2 genotypes and a corresponding haplotype are linked with breast cancer risk in a German population.

Authors:  Christina Justenhoven; Ute Hamann; Beate Pesch; Volker Harth; Sylvia Rabstein; Christian Baisch; Caren Vollmert; Thomas Illig; Yon-Dschun Ko; Thomas Brüning; Hiltrud Brauch
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  2004-12       Impact factor: 4.254

3.  Polymorphism in the ERCC2 codon 751 is associated with arsenic-induced premalignant hyperkeratosis and significant chromosome aberrations.

Authors:  Mayukh Banerjee; Jyotirmoy Sarkar; Jayanta K Das; Angshuman Mukherjee; Ajoy K Sarkar; Lakshmikanta Mondal; Ashok K Giri
Journal:  Carcinogenesis       Date:  2006-10-17       Impact factor: 4.944

Review 4.  ERCC2/XPD gene polymorphisms and cancer risk.

Authors:  Simone Benhamou; Alain Sarasin
Journal:  Mutagenesis       Date:  2002-11       Impact factor: 3.000

5.  The role of viral phenotype and CCR-5 gene defects in HIV-1 transmission and disease progression.

Authors:  N L Michael; G Chang; L G Louie; J R Mascola; D Dondero; D L Birx; H W Sheppard
Journal:  Nat Med       Date:  1997-03       Impact factor: 53.440

6.  Resistance to HIV-1 infection in caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene.

Authors:  M Samson; F Libert; B J Doranz; J Rucker; C Liesnard; C M Farber; S Saragosti; C Lapoumeroulie; J Cognaux; C Forceille; G Muyldermans; C Verhofstede; G Burtonboy; M Georges; T Imai; S Rana; Y Yi; R J Smyth; R G Collman; R W Doms; G Vassart; M Parmentier
Journal:  Nature       Date:  1996-08-22       Impact factor: 49.962

7.  Drug-induced apoptosis is delayed and reduced in XPD lymphoblastoid cell lines: possible role of TFIIH in p53-mediated apoptotic cell death.

Authors:  A I Robles; X W Wang; C C Harris
Journal:  Oncogene       Date:  1999-08-19       Impact factor: 9.867

8.  Genetic restriction of HIV-1 infection and progression to AIDS by a deletion allele of the CKR5 structural gene. Hemophilia Growth and Development Study, Multicenter AIDS Cohort Study, Multicenter Hemophilia Cohort Study, San Francisco City Cohort, ALIVE Study.

Authors:  M Dean; M Carrington; C Winkler; G A Huttley; M W Smith; R Allikmets; J J Goedert; S P Buchbinder; E Vittinghoff; E Gomperts; S Donfield; D Vlahov; R Kaslow; A Saah; C Rinaldo; R Detels; S J O'Brien
Journal:  Science       Date:  1996-09-27       Impact factor: 47.728

9.  Predictors of disease progression in HIV infection: a review.

Authors:  Simone E Langford; Jintanat Ananworanich; David A Cooper
Journal:  AIDS Res Ther       Date:  2007-05-14       Impact factor: 2.250

10.  Analysis of variants in DNA damage signalling genes in bladder cancer.

Authors:  Ananya Choudhury; Faye Elliott; Mark M Iles; Michael Churchman; Robert G Bristow; D Timothy Bishop; Anne E Kiltie
Journal:  BMC Med Genet       Date:  2008-07-18       Impact factor: 2.103
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  2 in total

1.  A haplotype in the CCR5 gene promoter was associated with the susceptibility to HIV-1 infection in a northern Chinese population.

Authors:  Lidan Xu; Yuandong Qiao; Xuelong Zhang; Haiming Sun; Jingwei Wang; Donglin Sun; Xueyuan Jia; Chao Shen; Yanling Zhao; Yan Jin; Yang Yu; Hong Ling; Kaili Wang; Songbin Fu
Journal:  Mol Biol Rep       Date:  2010-04-04       Impact factor: 2.316

2.  XPB mediated retroviral cDNA degradation coincides with entry to the nucleus.

Authors:  Kristine E Yoder; William Roddick; Pia Hoellerbauer; Richard Fishel
Journal:  Virology       Date:  2010-12-17       Impact factor: 3.616
  2 in total

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