OBJECTIVE: To compare the modalities of treatment for male hypogonadism available in Brazil. METHODS:Thirty-two men with late-onset hypogonadism ('andropause') were followed-up in the Hospital de Guarnição de Florianópolis, in Florianópolis, south Brazil. Clinical diagnosis was established according to AMS questionnaire (positive if equal to or higher than 27 points), and laboratory diagnosis was made through low values of total testosterone (under 300 ng/dL) and/or free calculated testosterone (under 6.5 ng/dL). Patients were randomized to three non-enteral treatment groups (Deposteron--11 patients; Durateston--11 patients; and Nebido--10 patients). RESULTS: Clinically, Nebido seemed to be superior when compared to Deposteron (mean value of improvement percentage; p = 0.03) and when compared to Durateston (post-treatment average AMS score; p = 0.03). According to laboratory analysis, Nebido showed higher testosterone levels than Deposteron and Durateston (p < 0.001). CONCLUSIONS: All non-enteral testosterone formulas available in the Brazilian market are efficient in raising testosterone levels and in clinical improvement of hypogonadal patients. Nebido showed both a better clinical and laboratory effectiveness.
RCT Entities:
OBJECTIVE: To compare the modalities of treatment for male hypogonadism available in Brazil. METHODS: Thirty-two men with late-onset hypogonadism ('andropause') were followed-up in the Hospital de Guarnição de Florianópolis, in Florianópolis, south Brazil. Clinical diagnosis was established according to AMS questionnaire (positive if equal to or higher than 27 points), and laboratory diagnosis was made through low values of total testosterone (under 300 ng/dL) and/or free calculated testosterone (under 6.5 ng/dL). Patients were randomized to three non-enteral treatment groups (Deposteron--11 patients; Durateston--11 patients; and Nebido--10 patients). RESULTS: Clinically, Nebido seemed to be superior when compared to Deposteron (mean value of improvement percentage; p = 0.03) and when compared to Durateston (post-treatment average AMS score; p = 0.03). According to laboratory analysis, Nebido showed higher testosterone levels than Deposteron and Durateston (p < 0.001). CONCLUSIONS: All non-enteral testosterone formulas available in the Brazilian market are efficient in raising testosterone levels and in clinical improvement of hypogonadal patients. Nebido showed both a better clinical and laboratory effectiveness.
Authors: Daniel Pantoja Estumano; Luan Oliveira Ferreira; Paulo Augusto Lima Bezerra; Maria Clara Pinheiro da Silva; Giovanna Coutinho Jardim; George Francisco Souza Santos; Kayo Silva Gustavo; Bruna Gerrits Mattos; Jorge Amando Batista Ramos; Vanessa Jóia de Mello; Edmar Tavares da Costa; Dielly Catrina Favacho Lopes; Moisés Hamoy Journal: Front Endocrinol (Lausanne) Date: 2019-09-24 Impact factor: 5.555
Authors: Rastafa I Geddes; Amita Kapoor; Kentaro Hayashi; Ryan Rauh; Marlyse Wehber; Quinn Bongers; Alex D Jansen; Icelle M Anderson; Gabrielle Farquhar; Sivan Vadakkadath-Meethal; Toni E Ziegler; Craig S Atwood Journal: Endocrinol Diabetes Metab Date: 2021-03-18