| Literature DB >> 201263 |
Abstract
The histological changes in the regional thoracic lymph nodes of rats exposed to silica dust by inhalation are recorded. A dual response is noted involving both inflammatory and immune mechanisms, resulting in a fibroblastic connective tissue reaction and a plasma-cell-macrophage interaction. It is proposed that the progressive silicotic lesions obstruct the lymphatic channels in the lymph nodes, thus interfering with the lymph drainage from the lung and aggravating the silicotic process in the lung itself.Entities:
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Year: 1977 PMID： 201263 PMCID： PMC2041254
Source DB: PubMed Journal: Br J Exp Pathol ISSN： 0007-1021