PURPOSE OF REVIEW: This review gives a broad overview of the key factors of ischemic injury to the liver and presents the current modifications of preservation solutions and the few strategies of biological modulation in clinical use today. RECENT FINDINGS: Protective effects in human-liver transplantation were shown by methylprednisolone treatment in decreased donors, and by inhalation of a nontoxic dose of nitric oxide in recipients. In addition, recent results showed rescue of pig livers, donated after cardiac death by application of a cocktail of substances addressing several previously identified mechanisms of ischemia-reperfusion injury. SUMMARY: The future of a pharmacological approach attenuating or preventing ischemia-reperfusion injury lies in a combination of drugs acting simultaneously on several steps of the injury cascades. Applying these substances during flush, before, and during implantation appears as an attractive strategy to protect extended criteria liver grafts.
PURPOSE OF REVIEW: This review gives a broad overview of the key factors of ischemic injury to the liver and presents the current modifications of preservation solutions and the few strategies of biological modulation in clinical use today. RECENT FINDINGS: Protective effects in human-liver transplantation were shown by methylprednisolone treatment in decreased donors, and by inhalation of a nontoxic dose of nitric oxide in recipients. In addition, recent results showed rescue of pig livers, donated after cardiac death by application of a cocktail of substances addressing several previously identified mechanisms of ischemia-reperfusion injury. SUMMARY: The future of a pharmacological approach attenuating or preventing ischemia-reperfusion injury lies in a combination of drugs acting simultaneously on several steps of the injury cascades. Applying these substances during flush, before, and during implantation appears as an attractive strategy to protect extended criteria liver grafts.
Authors: G Sgarbi; F Giannone; G A Casalena; A Baracca; M Baldassare; P Longobardi; P Caraceni; M Derenzini; G Lenaz; D Trerè; Giancarlo Solaini Journal: J Bioenerg Biomembr Date: 2011-10-21 Impact factor: 2.945
Authors: Michael J J Chu; Ryash Vather; Anthony J R Hickey; Anthony R J Phillips; Adam S J R Bartlett Journal: HPB (Oxford) Date: 2014-04-09 Impact factor: 3.647
Authors: Ricardo C Gehrau; Valeria R Mas; Catherine I Dumur; Jihee L Suh; Ashish K Sharma; Helen P Cathro; Daniel G Maluf Journal: Transplantation Date: 2015-12 Impact factor: 4.939
Authors: Ricardo C Gehrau; Valeria R Mas; Catherine I Dumur; Danielle E Ladie; Jihee L Suh; Samuel Luebbert; Daniel G Maluf Journal: Transplantation Date: 2013-11-27 Impact factor: 4.939