PURPOSE OF REVIEW: Type 1 diabetes (T1D) is an autoimmune disease typically believed to result from malfunctions in adaptive immune response signaling which result in activation of self-reactive T cells. However, recent research has indicated components of the innate immune response as having a key role in the initiation of the autoimmune process of T1D. This review will highlight recent studies which examined the role of innate immune response signaling and the connections to T1D pathogenesis. RECENT FINDINGS: Investigations indicate that components of innate immunity, including inflammation and Toll-like receptor signaling, are involved in pancreatic islet infiltration and insulitis. Recent studies examining the role of viral infections in T1D development also implicate innate immune response signaling in disease pathogenesis. SUMMARY: Current research indicates that components of innate immune response signaling are involved in the initiation of the autoimmune process which results in the eventual destruction of beta cells during T1D pathogenesis. Continuing efforts by researchers to uncover the molecular pathways of innate immunity linked to T1D development could potentially lead to therapeutics capable of preventing and curing the autoimmune disease.
PURPOSE OF REVIEW: Type 1 diabetes (T1D) is an autoimmune disease typically believed to result from malfunctions in adaptive immune response signaling which result in activation of self-reactive T cells. However, recent research has indicated components of the innate immune response as having a key role in the initiation of the autoimmune process of T1D. This review will highlight recent studies which examined the role of innate immune response signaling and the connections to T1D pathogenesis. RECENT FINDINGS: Investigations indicate that components of innate immunity, including inflammation and Toll-like receptor signaling, are involved in pancreatic islet infiltration and insulitis. Recent studies examining the role of viral infections in T1D development also implicate innate immune response signaling in disease pathogenesis. SUMMARY: Current research indicates that components of innate immune response signaling are involved in the initiation of the autoimmune process which results in the eventual destruction of beta cells during T1D pathogenesis. Continuing efforts by researchers to uncover the molecular pathways of innate immunity linked to T1D development could potentially lead to therapeutics capable of preventing and curing the autoimmune disease.
Authors: Fnu Nagajyothi; Regina Kuliawat; Christine M Kusminski; Fabiana S Machado; Mahalia S Desruisseaux; Dazhi Zhao; Gary J Schwartz; Huan Huang; Chris Albanese; Michael P Lisanti; Rajat Singh; Feng Li; Louis M Weiss; Stephen M Factor; Jeffrey E Pessin; Philipp E Scherer; Herbert B Tanowitz Journal: Am J Pathol Date: 2013-01-12 Impact factor: 4.307
Authors: Xue-Song Zhang; Yue Sandra Yin; Jincheng Wang; Thomas Battaglia; Kimberly Krautkramer; Wei Vivian Li; Jackie Li; Mark Brown; Meifan Zhang; Michelle H Badri; Abigail J S Armstrong; Christopher M Strauch; Zeneng Wang; Ina Nemet; Nicole Altomare; Joseph C Devlin; Linchen He; Jamie T Morton; John Alex Chalk; Kelly Needles; Viviane Liao; Julia Mount; Huilin Li; Kelly V Ruggles; Richard A Bonneau; Maria Gloria Dominguez-Bello; Fredrik Bäckhed; Stanley L Hazen; Martin J Blaser Journal: Cell Host Microbe Date: 2021-07-21 Impact factor: 31.316