Literature DB >> 20124705

Structure of bovine pancreatic ribonuclease complexed with uridine 5'-monophosphate at 1.60 A resolution.

Steven B Larson1, John S Day, Chieugiang Nguyen, Robert Cudney, Alexander McPherson.   

Abstract

Bovine pancreatic ribonuclease A (RNase A) was crystallized from a mixture of small molecules containing basic fuchsin, tobramycin and uridine 5'-monophosphate (U5P). Solution of the crystal structure revealed that the enzyme was selectively bound to U5P, with the pyrimidine ring of U5P residing in the pyrimidine-binding site at Thr45. The structure was refined to an R factor of 0.197 and an R(free) of 0.253.

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Year:  2010        PMID： 20124705      PMCID： PMC2815675          DOI： 10.1107/S174430910905194X

Source DB:  PubMed          Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun        ISSN： 1744-3091


  29 in total

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  2 in total

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