Literature DB >> 20123034

Trypanosoma cruzi-specific immune responses in subjects from endemic areas of Chagas disease of Argentina.

Gabriela C Olivera1, Maria C Albareda, Maria G Alvarez, Ana M De Rissio, Laura E Fichera, Gretchen Cooley, Pedro Yachelini, Hugo A Hrellac, Hilda Riboldi, Susana A Laucella, Rick L Tarleton, Miriam Postan.   

Abstract

Trypanosoma cruzi-specific immune responses were evaluated in a total of 88 subjects living in areas endemic of Chagas disease of Argentina by IFN-gamma ELISPOT assays and immunoblotting. Positive T. cruzi antigen-induced IFN-gamma responses were detected in 42% of subjects evaluated (15/26 positive by conventional serology and 22/62 seronegative subjects). Using immunoblotting, T. cruzi-specific IgG reactivity was detected in all seropositive subjects and in 11% (7/61) of subjects negative by conventional serology. Measurements of T cell responses and antibodies by immunoblotting, in conjunction with conventional serology, might enhance the capability of detection of exposure to T. cruzi in endemic areas. Copyright 2010 Elsevier Masson SAS. All rights reserved.

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Year:  2010        PMID： 20123034      PMCID： PMC2856734          DOI： 10.1016/j.micinf.2010.01.011

Source DB:  PubMed          Journal:  Microbes Infect        ISSN： 1286-4579            Impact factor:   2.700


  12 in total

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  9 in total

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