| Literature DB >> 20123008 |
S Mascia1, C Seiler, S Fitzpatrick, D I Wilson.
Abstract
An experimental investigation of extrusion-spheronisation (E-S) of a novel microcrystalline cellulose (MCC) formulation, comprising dimethyl sulfoxide (DMSO) as the granulating liquid, is reported. The extrusion-spheronisation performance of DMSO/MCC pastes is compared to that of similar water/MCC formulations and their rheological behaviours similarly assessed using lubricated squeeze flow. A case study involving water, DMSO and anhydrous ethanol yields important information regarding the physico-chemical properties necessary for solvents to be suitable for the extrusion of MCC. Copyright 2010 Elsevier B.V. All rights reserved.Entities:
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Year: 2010 PMID： 20123008 DOI： 10.1016/j.ijpharm.2009.12.058
Source DB: PubMed Journal: Int J Pharm ISSN： 0378-5173 Impact factor: 5.875