| Literature DB >> 20122981 |
Tanmoy Rana1, Asit Kumar Bera, Subhashree Das, Diganta Pan, Subhasish Bandyopadhyay, Debasis Bhattacharya, Sumanta De, Sourav Sikdar, Subrata Kumar Das.
Abstract
Ascorbic acid is a sugar acid and an essential vital food nutrient found mainly in fruits and vegetables. The purpose of this study was to investigate the effects of ascorbic acid against arsenic induced oxidative stress in blood of rat. In rat, treatment with ascorbic acid prevented the increased serum enzymatic activity of AST, ALT, ALP, ACP and LDH. In addition, treatment with ascorbic acid prevented elevated production of LPO, PC and NO and restored the depletion of reduced SOD and CAT activities. Interestingly, ascorbic acid markedly upregulated lymphocytes relative mRNA expression of lymphocytes SOD2 gene corresponding to GAPDH, house keeping candidate gene in arsenic-treated rat, which might provide anti-oxidative activity in the blood. 2010 Elsevier Ltd. All rights reserved.Entities:
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Year: 2010 PMID： 20122981 DOI： 10.1016/j.fct.2010.01.027
Source DB: PubMed Journal: Food Chem Toxicol ISSN： 0278-6915 Impact factor: 6.023