Cristina Delgado-Andrade1, Isabel Seiquer2, Marta Mesías García2, Gabriel Galdó3, M Pilar Navarro2. 1. Unit of Nutrition, Estación Experimental del Zaidín, High Spanish Council for Scientific Research, Granada, Spain. Electronic address: cdelgado@eez.csic.es. 2. Unit of Nutrition, Estación Experimental del Zaidín, High Spanish Council for Scientific Research, Granada, Spain. 3. Department of Pediatrics, San Cecilio University Hospital, Granada, Spain.
Abstract
OBJECTIVE: To examine the effects of consuming diets rich in Maillard reaction products (MRPs) on phosphorus bioavailability in male adolescents. METHODS: A 2-wk randomized two-period crossover trial was performed among healthy male adolescents aged 11-14 y (n = 20), with a 40-d washout period. The diets consumed were rich (brown diet) or poor (white diet) in MRPs. Three-day balances were performed on the last of each dietary period, and fasting blood samples were obtained. Dietary phosphorus utilization was examined by phosphorus intake in diet and phosphorus output in feces and urine, as measured colorimetrically by the vanadomolibdate procedure. Serum phosphorus, parathyroid hormone, and total alkaline phosphatase were determined. RESULTS: A tendency to increase daily phosphorus fecal excretion was observed subsequent to the brown diet consumption compared with the white diet (P = 0.10), which led to significant reductions in phosphorus apparent absorption (P = 0.03) and fractional absorption (P = 0.04). Values of apparent phosphorus retention and bioavailability tended to decrease after the high-MRP diet. Serum parameters analyzed remained unchanged between diets and were within normal values. CONCLUSION: The consumption of a rich-MRP diet in male adolescents had a negative influence on dietary phosphorus absorption, tending to decrease the phosphorus balance. Given the actual dietary habits of adolescents, possible long-term repercussions of this kind of diet should be studied.
RCT Entities:
OBJECTIVE: To examine the effects of consuming diets rich in Maillard reaction products (MRPs) on phosphorus bioavailability in male adolescents. METHODS: A 2-wk randomized two-period crossover trial was performed among healthy male adolescents aged 11-14 y (n = 20), with a 40-d washout period. The diets consumed were rich (brown diet) or poor (white diet) in MRPs. Three-day balances were performed on the last of each dietary period, and fasting blood samples were obtained. Dietary phosphorus utilization was examined by phosphorus intake in diet and phosphorus output in feces and urine, as measured colorimetrically by the vanadomolibdate procedure. Serum phosphorus, parathyroid hormone, and total alkaline phosphatase were determined. RESULTS: A tendency to increase daily phosphorus fecal excretion was observed subsequent to the brown diet consumption compared with the white diet (P = 0.10), which led to significant reductions in phosphorus apparent absorption (P = 0.03) and fractional absorption (P = 0.04). Values of apparent phosphorus retention and bioavailability tended to decrease after the high-MRP diet. Serum parameters analyzed remained unchanged between diets and were within normal values. CONCLUSION: The consumption of a rich-MRP diet in male adolescents had a negative influence on dietary phosphorus absorption, tending to decrease the phosphorus balance. Given the actual dietary habits of adolescents, possible long-term repercussions of this kind of diet should be studied.
Authors: Scott T McClure; Casey M Rebholz; Sibyl Medabalimi; Emily A Hu; Zhe Xu; Elizabeth Selvin; Lawrence J Appel Journal: Am J Clin Nutr Date: 2019-05-01 Impact factor: 7.045