Murli Krishna1. 1. Department of Pathology, Mayo Clinic Florida, 4500 San Pablo Road, Jacksonville, FL 32224, USA. krishna.murli@mayo.edu
Abstract
CONTEXT: It is important to determine the type and/or site of origin of metastatic tumors for optimal clinical management. OBJECTIVE: To summarize the use of currently available immunohistochemical markers in the evaluation of metastatic tumors. DATA SOURCES: Review of relevant literature on immunohistochemical evaluation of tumors and the author's personal experience. CONCLUSIONS: Immunohistochemistry is an important ancillary technique for evaluation of metastatic tumors and should be used in the context of routine morphology and clinical information. While a single marker may be used to support a known or suspected site of origin, a carefully constructed panel is strongly recommended, particularly for tumors of morphologically uncertain lineage or origin.
CONTEXT: It is important to determine the type and/or site of origin of metastatic tumors for optimal clinical management. OBJECTIVE: To summarize the use of currently available immunohistochemical markers in the evaluation of metastatic tumors. DATA SOURCES: Review of relevant literature on immunohistochemical evaluation of tumors and the author's personal experience. CONCLUSIONS: Immunohistochemistry is an important ancillary technique for evaluation of metastatic tumors and should be used in the context of routine morphology and clinical information. While a single marker may be used to support a known or suspected site of origin, a carefully constructed panel is strongly recommended, particularly for tumors of morphologically uncertain lineage or origin.
Authors: Natasha M Savage; Cargill H Alleyne; John R Vender; Ramon Figueroa; Hui Zhang; Thomas A Samuel; Suash Sharma Journal: Int J Clin Exp Pathol Date: 2011-06-16
Authors: Leila Moosavi; Carlos D'Assumpcao; Jonathan Bowen; Arash Heidari; Everardo Cobos Journal: J Investig Med High Impact Case Rep Date: 2019 Jan-Dec