AIMS: To investigate the relationship between levels of insulin-like growth factors 1 and 2 (IGF-1, IGF-2), and insulin-like growth factor binding protein 3 (IGFBP-3) in antenatal maternal serum and gestational age at delivery. METHODS: Prospective cohort study of 1650 low-risk Caucasian women in a London University teaching hospital. Maternal IGF-1, IGF-2 and IGFBP-3 were measured in maternal blood at booking and analyzed with respect to gestational age at delivery. RESULTS: There was no significant association between maternal IGF-1 or IGF-2 and preterm birth (PTB). A significant reduction in mean IGFBP-3 levels was noted with delivery <32 completed weeks (P=0.02). CONCLUSION: Maternal mean IGFBP-3 levels are significantly reduced in cases complicated by delivery <32 completed weeks.
AIMS: To investigate the relationship between levels of insulin-like growth factors 1 and 2 (IGF-1, IGF-2), and insulin-like growth factor binding protein 3 (IGFBP-3) in antenatal maternal serum and gestational age at delivery. METHODS: Prospective cohort study of 1650 low-risk Caucasian women in a London University teaching hospital. Maternal IGF-1, IGF-2 and IGFBP-3 were measured in maternal blood at booking and analyzed with respect to gestational age at delivery. RESULTS: There was no significant association between maternal IGF-1 or IGF-2 and preterm birth (PTB). A significant reduction in mean IGFBP-3 levels was noted with delivery <32 completed weeks (P=0.02). CONCLUSION: Maternal mean IGFBP-3 levels are significantly reduced in cases complicated by delivery <32 completed weeks.
Authors: Roberto Romero; Eleazar Soto; Stanley M Berry; Sonia S Hassan; Juan Pedro Kusanovic; Bo Hyun Yoon; Samuel Edwin; Moshe Mazor; Tinnakorn Chaiworapongsa Journal: J Matern Fetal Neonatal Med Date: 2011-12-20
Authors: Ritva Haataja; Minna K Karjalainen; Aino Luukkonen; Kari Teramo; Hilkka Puttonen; Marja Ojaniemi; Teppo Varilo; Bimal P Chaudhari; Jevon Plunkett; Jeffrey C Murray; Steven A McCarroll; Leena Peltonen; Louis J Muglia; Aarno Palotie; Mikko Hallman Journal: PLoS Genet Date: 2011-02-03 Impact factor: 5.917
Authors: Elise N A Bream; Cara R Leppellere; Margaret E Cooper; John M Dagle; David C Merrill; Kaare Christensen; Hyagriv N Simhan; Chin-To Fong; Mikko Hallman; Louis J Muglia; Mary L Marazita; Jeffrey C Murray Journal: Pediatr Res Date: 2012-11-20 Impact factor: 3.756