Literature DB >> 20121474

2D DIGE of the cerebrospinal fluid proteome in neurological diseases.

Hayrettin Tumani1, Vera Lehmensiek, Stefan Lehnert, Markus Otto, Johannes Brettschneider.   

Abstract

2D DIGE is a promising approach to comparative proteome analysis known for a high sensitivity and high reproducibility compared with classical 2DE techniques. It offers new possibilities for the detection of cerebrospinal fluid (CSF) biomarkers in neurological diseases, such as dementia, amyotrophic lateral sclerosis or multiple sclerosis. We review the first studies using 2D DIGE for analysis of the CSF proteome in neurological diseases and discuss advantages, as well as drawbacks, of the methodological approach with special emphasis on CSF-related aspects.

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Year:  2010        PMID： 20121474     DOI： 10.1586/epr.09.99

Source DB:  PubMed          Journal:  Expert Rev Proteomics        ISSN： 1478-9450            Impact factor:   3.940


  8 in total

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7.  Proteomic identification of proteins suggestive of immune-mediated response or neuronal degeneration in serum of achalasia patients.

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Journal:  Gut Liver       Date:  2013-06-11       Impact factor: 4.519

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  8 in total

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