Literature DB >> 2012076

Interleukin-6 positive follicular hyperplasia in the lymph node of a patient with rheumatoid arthritis.

Y Numata1, Y Matsuura, S Onishi, Y Yamamoto, F Ohno, H Tagoh, K Yoshizaki, S Fujimoto, H Yamamoto.   

Abstract

We examined interleukin-6 production in the hyperplastic lymph node of a 77-year-old male rheumatoid arthritis patient with lymphadenopathy. The interleukin-6 production of the lymph node was observed by both immunohistological staining and in vitro culture. The results suggest that interleukin-6 plays a significant pathogenic role in the etiology of the lymphadenopathy seen in many rheumatoid arthritis patients.

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Year:  1991        PMID: 2012076     DOI: 10.1002/ajh.2830360412

Source DB:  PubMed          Journal:  Am J Hematol        ISSN: 0361-8609            Impact factor:   10.047


  2 in total

Review 1.  Therapy of rheumatoid arthritis by blocking IL-6 signal transduction with a humanized anti-IL-6 receptor antibody.

Authors:  K Yoshizaki; N Nishimoto; M Mihara; T Kishimoto
Journal:  Springer Semin Immunopathol       Date:  1998

2.  A case of rheumatoid arthritis and limited systemic sclerosis overlap successfully treated with tocilizumab for arthritis and concomitant generalized lymphadenopathy and primary biliary cirrhosis.

Authors:  Eiko Saito; Shinji Sato; Shinichi Nogi; Noriko Sasaki; Naofumi Chinen; Kiri Honda; Takayuki Wakabayashi; Chiho Yamada; Naoya Nakamura; Yasuo Suzuki
Journal:  Case Rep Rheumatol       Date:  2014-04-15
  2 in total

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