Literature DB >> 20119639

On a new strategy of preventive oncology.

L N Mkrtchyan1.   

Abstract

The etiology of cancer is much wider than separately taken causal agent and rests against the most complicated interrelation and mutuality of many external and internal influences. Our researches with use of fluorescing antibodies to AFP, CEA and Ca-19-9 have shown that they are intensively besieged on a surface of cultivated malignant cells. It is the basic mechanism of tolerance and immunological escape, which is similar to pregnancy when "the maximal immunological most favored status" to developing fetus (semiallogenic transplant) is provided. The earliest revealing of first cancer cells, before steady community of cells and tumor angiogenesis were formed, has particular importance in the fight against cancer. The necessity of the specific completion of the weakened antineoplastic resistibility of people from high oncological risk groups is substantiated. The activity in this direction brought forth the design of embryonic anti-tumor modulator (EATM). EATM is composed of a wide pool of fetal proteins and proteoglycans isolated exceptionally from normal embryonic substances.

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Year:  2010        PMID: 20119639     DOI: 10.1007/s11064-009-0110-x

Source DB:  PubMed          Journal:  Neurochem Res        ISSN: 0364-3190            Impact factor:   3.996


  7 in total

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Review 2.  Stem cells, cancer, and cancer stem cells.

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Review 3.  Can fetal antigens be used for prophylactic immunization?

Authors:  P B Medawar; R Hunt
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Review 4.  Cancer and pregnancy share similar mechanisms of immunological escape.

Authors:  Jacek R Wilczyński
Journal:  Chemotherapy       Date:  2006-04-04       Impact factor: 2.544

Review 5.  Normal stem cells and cancer stem cells: the niche matters.

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Journal:  Cancer Res       Date:  2006-05-01       Impact factor: 12.701

6.  Cancer precursors and their control by BCG.

Authors:  S R Rosenthal
Journal:  Dev Biol Stand       Date:  1986

7.  Intrinsic resistance of tumorigenic breast cancer cells to chemotherapy.

Authors:  Xiaoxian Li; Michael T Lewis; Jian Huang; Carolina Gutierrez; C Kent Osborne; Meng-Fen Wu; Susan G Hilsenbeck; Anne Pavlick; Xiaomei Zhang; Gary C Chamness; Helen Wong; Jeffrey Rosen; Jenny C Chang
Journal:  J Natl Cancer Inst       Date:  2008-04-29       Impact factor: 13.506

  7 in total

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