Cardiac Motion Analysis in Ischemic and Non-Ischemic Cardiomyopathy Using Parallel Transport.

In this study, we used the multi-detector computed tomographic (MDCT) images of heart left ventricles at end-diastole and end-systole to perform quantitative analysis and comparison of heart motion in patients with anterior wall myocardial infarction and ischemic cardiomyopathy (ICM) versus those with global non-ischemic cardiomyopathy (NICM). MDCT ventricular images of 25 subjects (13 with ICM) with ejection fraction (EF)< 35% were analyzed. We used parallel transport in diffeomorphism under the large deformation diffeomorphic metric mapping framework to translate within subject motion related deformation in a global template coordinate system. We then performed a hypothesis testing on the ventricular motion variation in the global template coordinate. Statistical analysis indicates that there are meaningful ventricular motion differences between ICM and NICM groups. Additionally, subjects with ICM demonstrated less wall thickening at ES in the anterior wall where the pathology is located.