Literature DB >> 20118634

Proteomics analysis of cardiac muscle from rats with peroxisomal proliferator-activated receptor alpha (PPARalpha) stimulation.

Masafumi Miyazaki1, Ippei Nakagawa, Shigeru Koga, Yasushi Kasahara, Matthew P Patricelli.   

Abstract

To investigate peroxisomal proliferator-activated receptor alpha (PPARalpha) signal responses in heart muscle, we performed LC-MS/MS-based proteomics analysis of heart muscle from rats given fenofibrate or clofibrate. Fenofibrate increased the expression of ACAA2, DECR1, and ECH1 consistent with activation of PPARalpha. Fenofibrate and clofibrate reduced the expression of 10 and 12 proteins, respectively with the expression of ACSL1, SLC25A4, A1BG, HADHA, ATP2A2, BDH1, ETFDH, HADHB, and CPT2 being reduced in common with both of fibrate-treated groups. The approach adopted in this study provides an efficient method for monitoring global changes in protein expression.

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Year:  2010        PMID： 20118634     DOI： 10.2131/jts.35.131

Source DB:  PubMed          Journal:  J Toxicol Sci        ISSN： 0388-1350            Impact factor:   2.196


  8 in total

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4.  Bioinformatics-driven identification and examination of candidate genes for non-alcoholic fatty liver disease.

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Journal:  PLoS One       Date:  2011-01-27       Impact factor: 3.240

5.  MicroRNA-21 regulates peroxisome proliferator-activated receptor alpha, a molecular mechanism of cardiac pathology in Cardiorenal Syndrome Type 4.

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  8 in total

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