BACKGROUND: The relatives of individuals with schizophrenia exhibit deficits of overall frontal lobe volume, consistent with a genetic contribution to these deficits. AIMS: To quantify the structure of gyral-defined subregions of prefrontal cortex in individuals with schizophrenia and their siblings. METHOD: Grey matter volume, cortical thickness, and surface area of the superior, middle and inferior frontal gyri were measured in participants with schizophrenia and their unaffected (non-psychotic) siblings (n = 26 pairs), and controls and their siblings (n = 40 pairs). RESULTS: Grey matter volume was reduced in the middle and inferior frontal gyri of individuals with schizophrenia, relative to controls. However, only inferior frontal gyrus volume was also reduced in the unaffected siblings of those with schizophrenia, yielding a volume intermediate between their affected siblings and controls. CONCLUSIONS: The structure of subregions of the prefrontal cortex may be differentially influenced by genetic factors in schizophrenia, with inferior frontal gyrus volume being most related to familial risk.
BACKGROUND: The relatives of individuals with schizophrenia exhibit deficits of overall frontal lobe volume, consistent with a genetic contribution to these deficits. AIMS: To quantify the structure of gyral-defined subregions of prefrontal cortex in individuals with schizophrenia and their siblings. METHOD: Grey matter volume, cortical thickness, and surface area of the superior, middle and inferior frontal gyri were measured in participants with schizophrenia and their unaffected (non-psychotic) siblings (n = 26 pairs), and controls and their siblings (n = 40 pairs). RESULTS: Grey matter volume was reduced in the middle and inferior frontal gyri of individuals with schizophrenia, relative to controls. However, only inferior frontal gyrus volume was also reduced in the unaffected siblings of those with schizophrenia, yielding a volume intermediate between their affected siblings and controls. CONCLUSIONS: The structure of subregions of the prefrontal cortex may be differentially influenced by genetic factors in schizophrenia, with inferior frontal gyrus volume being most related to familial risk.
Authors: Karl-Anton Dorph-Petersen; Joseph N Pierri; James M Perel; Zhuoxin Sun; Allan R Sampson; David A Lewis Journal: Neuropsychopharmacology Date: 2005-09 Impact factor: 7.853
Authors: T D Cannon; T G van Erp; M Huttunen; J Lönnqvist; O Salonen; L Valanne; V P Poutanen; C G Standertskjöld-Nordenstam; R E Gur; M Yan Journal: Arch Gen Psychiatry Date: 1998-12
Authors: Andrew M McIntosh; Dominic E Job; William J Moorhead; Lesley K Harrison; Heather C Whalley; Eve C Johnstone; Stephen M Lawrie Journal: Am J Med Genet B Neuropsychiatr Genet Date: 2006-01-05 Impact factor: 3.568
Authors: Zainab Delawalla; Deanna M Barch; Jennifer L Fisher Eastep; Emily S Thomason; Melissa J Hanewinkel; Paul A Thompson; John G Csernansky Journal: Schizophr Bull Date: 2006-05-19 Impact factor: 9.306
Authors: Daniel R Calabrese; Lei Wang; Michael P Harms; J Tilak Ratnanather; Deanna M Barch; C Robert Cloninger; Paul A Thompson; Michael I Miller; John G Csernansky Journal: Schizophr Res Date: 2008-08-09 Impact factor: 4.939
Authors: J Tilak Ratnanather; Clare B Poynton; Dominic V Pisano; Britni Crocker; Elizabeth Postell; Shannon Cebron; Elvan Ceyhan; Nancy A Honeycutt; Pamela B Mahon; Patrick E Barta Journal: Schizophr Res Date: 2013-09-06 Impact factor: 4.939
Authors: Toshiyuki Ohtani; Elisabetta Del Re; James J Levitt; Margaret Niznikiewicz; Jun Konishi; Takeshi Asami; Toshiro Kawashima; Tomohide Roppongi; Paul G Nestor; Martha E Shenton; Dean F Salisbury; Robert W McCarley Journal: Brain Struct Funct Date: 2018-04-18 Impact factor: 3.270
Authors: Max de Leeuw; Marc M Bohlken; René Cw Mandl; Manon Hj Hillegers; René S Kahn; Matthijs Vink Journal: Neuropsychopharmacology Date: 2016-07-21 Impact factor: 7.853
Authors: Lynn D Selemon; Can Ceritoglu; J Tilak Ratnanather; Lei Wang; Michael P Harms; Kristina Aldridge; Anita Begović; John G Csernansky; Michael I Miller; Pasko Rakic Journal: J Comp Neurol Date: 2013-04-01 Impact factor: 3.215
Authors: Jodi M Gilman; John K Kuster; Sang Lee; Myung Joo Lee; Byoung Woo Kim; Nikos Makris; Andre van der Kouwe; Anne J Blood; Hans C Breiter Journal: J Neurosci Date: 2014-04-16 Impact factor: 6.167