BACKGROUND: A significant association between joint hypermobility syndrome (JHS) and panic disorder was observed in a sample of rheumatology outpatients. OBJECTIVE: The aim of this study was to assess whether JHS is more frequent in panic-disorder than in control subjects. METHOD: The authors conducted a case-control study comparing 55 untreated patients with panic disorder and three matched-control groups: psychiatric patients, fibromyalgia patients, and healthy persons. RESULTS: JHS was more frequent among panic-disorder than among psychiatric patients, the healthy group, or the fibromyalgia group. In the panic-disorder group, there was a significant correlation between severity of JHS and anxiety. CONCLUSION: The strong association between JHS and panic disorder points to a genetic association. There is also a possibility that JHS and mitral valve prolapse, another condition frequently associated with panic disorder, share a common pathophysiological mechanism.
BACKGROUND: A significant association between joint hypermobility syndrome (JHS) and panic disorder was observed in a sample of rheumatology outpatients. OBJECTIVE: The aim of this study was to assess whether JHS is more frequent in panic-disorder than in control subjects. METHOD: The authors conducted a case-control study comparing 55 untreated patients with panic disorder and three matched-control groups: psychiatricpatients, fibromyalgiapatients, and healthy persons. RESULTS: JHS was more frequent among panic-disorder than among psychiatricpatients, the healthy group, or the fibromyalgia group. In the panic-disorder group, there was a significant correlation between severity of JHS and anxiety. CONCLUSION: The strong association between JHS and panic disorder points to a genetic association. There is also a possibility that JHS and mitral valve prolapse, another condition frequently associated with panic disorder, share a common pathophysiological mechanism.
Authors: Jessica A Eccles; Felix D C Beacher; Marcus A Gray; Catherine L Jones; Ludovico Minati; Neil A Harrison; Hugo D Critchley Journal: Br J Psychiatry Date: 2012-04-26 Impact factor: 9.319
Authors: Jessica A Eccles; Andrew P Owens; Christopher J Mathias; Satoshi Umeda; Hugo D Critchley Journal: Front Neurosci Date: 2015-02-10 Impact factor: 4.677
Authors: Satoshi Umeda; Neil A Harrison; Marcus A Gray; Christopher J Mathias; Hugo D Critchley Journal: Front Neurosci Date: 2015-03-17 Impact factor: 4.677