Literature DB >> 20117843

Substance P downregulates expression of the high affinity IgE receptor (FcepsilonRI) by human mast cells.

Christine McCary1, Brian P Tancowny, Adriana Catalli, Leslie C Grammer, Kathleen E Harris, Robert P Schleimer, Marianna Kulka.   

Abstract

The effect of the neuropeptide substance P (SP) on human mast cell (MC) phenotype is poorly understood. In this study, SP effects on human MC expression of the high affinity IgE receptor (FcepsilonRI) were characterized. SP downregulated expression of FcepsilonRI mRNA and protein by approximately 50% and in a concentration dependent manner, the effect was partially mediated by engagement of the neurokinin-1 receptor (NK1R) and resulted in reduced mast cell activation. Sensitization of MC with IgE prior to SP exposure protected MC from SP-mediated FcepsilonRI downregulation. SP release may inhibit MC responses to allergens and these results may have implications in neuroinflammatiion and stress. Crown Copyright 2010. Published by Elsevier B.V. All rights reserved.

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Year:  2010        PMID： 20117843      PMCID： PMC3712287          DOI： 10.1016/j.jneuroim.2009.12.006

Source DB:  PubMed          Journal:  J Neuroimmunol        ISSN： 0165-5728            Impact factor:   3.478


  32 in total

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