OBJECTIVE: To verify whether chromosomes 1, 4, and 6 have a role in determining oocyte viability. DESIGN: Retrospective study. SETTING: Reproductive Medicine Unit, Società Italiana Studi Medicina della Riproduzione, Bologna, Italy. PATIENT(S): Eighty-five patients with a normal karyotype who had undergone an assisted conception cycle with chromosomal analysis of first polar bodies for chromosomes 13, 15, 16, 18, 21, and 22 (first panel). A clinical pregnancy was obtained in 43 patients, whereas 42 patients were not pregnant. INTERVENTION(S): After conclusion of clinical pregnancies to delivery or abortion, first polar bodies from 85 patients were reanalyzed for chromosomes 1, 4, and 6 (second panel). MAIN OUTCOME MEASURE(S): Aneuploidy frequency, clinical pregnancy outcome. RESULT(S): The aneuploidy rate contributed by chromosome 1, 4, and 6 to the oocytes that were normal for the first panel was significantly higher in the nonpregnant patients (28%) versus the pregnant patients (11%), whereas no difference resulted between term pregnancies (11%) and abortions (10%). This trend was also observed when studying the first polar bodies from the oocytes that originated the transferred embryos. The frequency of aneuploidy for chromosomes 1 and 4 was comparable with that of chromosomes 15, 16, 21, and 22. CONCLUSION(S): Aneuploidy of chromosomes 1, 4, and 6 seems to be related to failed implantation and not to spontaneous abortions.
OBJECTIVE: To verify whether chromosomes 1, 4, and 6 have a role in determining oocyte viability. DESIGN: Retrospective study. SETTING: Reproductive Medicine Unit, Società Italiana Studi Medicina della Riproduzione, Bologna, Italy. PATIENT(S): Eighty-five patients with a normal karyotype who had undergone an assisted conception cycle with chromosomal analysis of first polar bodies for chromosomes 13, 15, 16, 18, 21, and 22 (first panel). A clinical pregnancy was obtained in 43 patients, whereas 42 patients were not pregnant. INTERVENTION(S): After conclusion of clinical pregnancies to delivery or abortion, first polar bodies from 85 patients were reanalyzed for chromosomes 1, 4, and 6 (second panel). MAIN OUTCOME MEASURE(S): Aneuploidy frequency, clinical pregnancy outcome. RESULT(S): The aneuploidy rate contributed by chromosome 1, 4, and 6 to the oocytes that were normal for the first panel was significantly higher in the nonpregnant patients (28%) versus the pregnant patients (11%), whereas no difference resulted between term pregnancies (11%) and abortions (10%). This trend was also observed when studying the first polar bodies from the oocytes that originated the transferred embryos. The frequency of aneuploidy for chromosomes 1 and 4 was comparable with that of chromosomes 15, 16, 21, and 22. CONCLUSION(S): Aneuploidy of chromosomes 1, 4, and 6 seems to be related to failed implantation and not to spontaneous abortions.
Authors: Joep Geraedts; Markus Montag; M Cristina Magli; Sjoerd Repping; Alan Handyside; Catherine Staessen; Joyce Harper; Andreas Schmutzler; John Collins; Veerle Goossens; Hans van der Ven; Katerina Vesela; Luca Gianaroli Journal: Hum Reprod Date: 2011-09-09 Impact factor: 6.918
Authors: Rola F Turki; Mourad Assidi; Huda A Banni; Hanan A Zahed; Sajjad Karim; Hans-Juergen Schulten; Muhammad Abu-Elmagd; Abdulrahim A Rouzi; Osama Bajouh; Hassan S Jamal; Mohammed H Al-Qahtani; Adel M Abuzenadah Journal: BMC Med Genet Date: 2016-10-10 Impact factor: 2.103
Authors: Joanne H Hsu; Hui Zeng; Kalistyn H Lemke; Aris A Polyzos; Jingly F Weier; Mei Wang; Anna R Lawin-O'Brien; Heinz-Ulrich G Weier; Benjamin O'Brien Journal: Int J Mol Sci Date: 2012-12-20 Impact factor: 5.923