| Literature DB >> 2011778 |
N Henderson1, V Stanescu, J Cauchoix.
Abstract
The nucleolytic action of chondroitinase ABC was studied by the use of rabbit lumbar intervertebral discs. The injection of one unit of enzyme results in necrosis of the nucleus pulposus. Radiologic, histologic, and biochemical changes were evident in discs studied 2 days after injection, and consistent nucleolysis was seen in those studied after 6 days. These results show that chondroitinase ABC deserves further evaluation as a possible chemonucleolytic enzyme.Entities:
Mesh：
Substances：
Year: 1991 PMID： 2011778
Source DB: PubMed Journal: Spine (Phila Pa 1976) ISSN： 0362-2436 Impact factor: 3.468