| Literature DB >> 20116225 |
Sailesh Malla1, Narayan Prasad Niraula, Bijay Singh, Kwangkyoung Liou, Jae Kyung Sohng.
Abstract
Doxorubicin (DXR), produced by Streptomyces peucetius ATCC 27952, exhibits potent antitumor activity against various cancer cell lines. Considerable time has lapsed since the biosynthesis of DXR and its overproduction was first summarized. Based on biosynthetic studies and product analysis, various factors affecting its production by the parental strain, S. peucetius ATCC 27952, are reviewed to better circumvent any bottlenecks in DXR production, thereby providing ideas to genetically engineered industrial strains of S. peucetius. Copyright 2009 Elsevier GmbH. All rights reserved.Entities:
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Year: 2010 PMID: 20116225 DOI: 10.1016/j.micres.2009.11.006
Source DB: PubMed Journal: Microbiol Res ISSN: 0944-5013 Impact factor: 5.415