Literature DB >> 2011600

Protective effect of transforming growth factor beta 1 on experimental autoimmune diseases in mice.

A P Kuruvilla1, R Shah, G M Hochwald, H D Liggitt, M A Palladino, G J Thorbecke.   

Abstract

Interleukin 1 (IL-1) and tumor necrosis factor alpha are thought to contribute to the inflammatory response associated with autoimmune diseases. Transforming growth factor beta 1 (TGF-beta 1) counteracts many effects of these cytokines and has various immunosuppressive properties. In the present study, it is shown that microgram amounts of TGF-beta 1, injected daily for 1-2 weeks, protect against collagen-induced arthritis (CIA) and relapsing experimental allergic encephalomyelitis (REAE), the animal models for rheumatoid arthritis and multiple sclerosis, respectively. When administered during induction of the disease, TGF-beta 1 prevents CIA but only delays the onset of REAE by 2-3 days. However, when administered during a remission. TGF-beta 1 prevents the occurrence of relapses in REAE. The results suggest that TGF-beta 1 has powerful anti-inflammatory effects, mimicking in some respects the beneficial effects of immunosuppressive drugs in these experimental models of autoimmune disease, but without discernable adverse effects.

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Year:  1991        PMID： 2011600      PMCID： PMC51351          DOI： 10.1073/pnas.88.7.2918

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  44 in total

1.  Immunosuppressive effect of FK506 on collagen-induced arthritis in rats.

Authors:  N Inamura; M Hashimoto; K Nakahara; H Aoki; I Yamaguchi; M Kohsaka
Journal:  Clin Immunol Immunopathol       Date:  1988-01

2.  Biological properties of recombinant human monocyte-derived interleukin 1 receptor antagonist.

Authors:  W P Arend; H G Welgus; R C Thompson; S P Eisenberg
Journal:  J Clin Invest       Date:  1990-05       Impact factor: 14.808

3.  Suppression of type II collagen-induced arthritis by intragastric administration of soluble type II collagen.

Authors:  C Nagler-Anderson; L A Bober; M E Robinson; G W Siskind; G J Thorbecke
Journal:  Proc Natl Acad Sci U S A       Date:  1986-10       Impact factor: 11.205

4.  Enhanced interleukin 1 generation by monocytes in vitro is temporally linked to an early event in the onset or exacerbation of rheumatoid arthritis.

Authors:  A Shore; S Jaglal; E C Keystone
Journal:  Clin Exp Immunol       Date:  1986-08       Impact factor: 4.330

5.  Experimental allergic encephalomyelitis in the Lewis rat. A model of predictable relapse by cyclophosphamide.

Authors:  H Minagawa; A Takenaka; Y Itoyama; R Mori
Journal:  J Neurol Sci       Date:  1987-04       Impact factor: 3.181

6.  Selective loss of suppressor T cells in rheumatoid arthritis patients: analysis of peripheral blood lymphocytes by 2-dimensional flow cytometry.

Authors:  M Goto; T Miyamoto; K Nishioka; K Okumura
Journal:  J Rheumatol       Date:  1986-10       Impact factor: 4.666

7.  Intrathecally administered natural human fibroblast interferon reduces exacerbations of multiple sclerosis. Results of a multicenter, double-blind study.

Authors:  L Jacobs; A M Salazar; R Herndon; P A Reese; A Freeman; R Jozefowicz; A Cuetter; F Husain; W A Smith; R Ekes
Journal:  Arch Neurol       Date:  1987-06

8.  Selective loss of the suppressor-inducer T-cell subset in progressive multiple sclerosis. Analysis with anti-2H4 monoclonal antibody.

Authors:  C Morimoto; D A Hafler; H L Weiner; N L Letvin; M Hagan; J Daley; S F Schlossman
Journal:  N Engl J Med       Date:  1987-01-08       Impact factor: 91.245

9.  Inhibition of cytokine production by cyclosporin A and transforming growth factor beta.

Authors:  T Espevik; I S Figari; M R Shalaby; G A Lackides; G D Lewis; H M Shepard; M A Palladino
Journal:  J Exp Med       Date:  1987-08-01       Impact factor: 14.307

10.  Inhibition of cytotoxic T cell development by transforming growth factor beta and reversal by recombinant tumor necrosis factor alpha.

Authors:  G E Ranges; I S Figari; T Espevik; M A Palladino
Journal:  J Exp Med       Date:  1987-10-01       Impact factor: 14.307
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  119 in total

1.  Metallothionein suppresses collagen-induced arthritis via induction of TGF-beta and down-regulation of proinflammatory mediators.

Authors:  J Youn; S-H Hwang; Z-Y Ryoo; M A Lynes; D-J Paik; H-S Chung; H-Y Kim
Journal:  Clin Exp Immunol       Date:  2002-08       Impact factor: 4.330

2.  Preventive effects of early anti-CD4 or anti-CD8 treatment on Borna disease in rats.

Authors:  L Stitz; M Sobbe; T Bilzer
Journal:  J Virol       Date:  1992-06       Impact factor: 5.103

3.  Segregated regulatory CD39+CD4+ T cell function: TGF-β-producing Foxp3- and IL-10-producing Foxp3+ cells are interdependent for protection against collagen-induced arthritis.

Authors:  Irina Kochetkova; Theresa Thornburg; Gayle Callis; David W Pascual
Journal:  J Immunol       Date:  2011-10-03       Impact factor: 5.422

4.  Hepatocyte growth factor inhibits CNS autoimmunity by inducing tolerogenic dendritic cells and CD25+Foxp3+ regulatory T cells.

Authors:  Mahdia Benkhoucha; Marie-Laure Santiago-Raber; Gregory Schneiter; Michel Chofflon; Hiroshi Funakoshi; Toshikazu Nakamura; Patrice H Lalive
Journal:  Proc Natl Acad Sci U S A       Date:  2010-03-23       Impact factor: 11.205

Review 5.  Transforming growth factor-beta in disease: the dark side of tissue repair.

Authors:  W A Border; E Ruoslahti
Journal:  J Clin Invest       Date:  1992-07       Impact factor: 14.808

6.  Effect of FK 506 on FK-binding protein and transforming growth factor beta gene expression.

Authors:  P Rao; H Sun; J Snyder; J J Fung; T E Starzl
Journal:  Transplant Proc       Date:  1991-12       Impact factor: 1.066

7.  Adrenomedullin protects from experimental arthritis by down-regulating inflammation and Th1 response and inducing regulatory T cells.

Authors:  Elena Gonzalez-Rey; Alejo Chorny; Francisco O'Valle; Mario Delgado
Journal:  Am J Pathol       Date:  2007-01       Impact factor: 4.307

8.  CD69 downregulates autoimmune reactivity through active transforming growth factor-beta production in collagen-induced arthritis.

Authors:  David Sancho; Manuel Gómez; Fernando Viedma; Enric Esplugues; Mónica Gordón-Alonso; María Angeles García-López; Hortensia de la Fuente; Carlos Martínez-A; Pilar Lauzurica; Francisco Sánchez-Madrid
Journal:  J Clin Invest       Date:  2003-09       Impact factor: 14.808

9.  TGF-beta signaling in dendritic cells is a prerequisite for the control of autoimmune encephalomyelitis.

Authors:  Yasmina Laouar; Terrence Town; David Jeng; Elise Tran; Yisong Wan; Vijay K Kuchroo; Richard A Flavell
Journal:  Proc Natl Acad Sci U S A       Date:  2008-07-31       Impact factor: 11.205

10.  Inhibitory effects of Helicobacter pylori infection on murine autoimmune gastritis.

Authors:  M Ohana; K Okazaki; C Oshima; K Kawasaki; T Fukui; H Tamaki; M Matsuura; M Asada; T Nishi; K Uchida; S Uose; H Nakase; M Iwano; Y Matsushima; H Hiai; T Chiba
Journal:  Gut       Date:  2003-08       Impact factor: 23.059
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